| Literature DB >> 15721239 |
Kimberley F Tolias1, Jay B Bikoff, Alain Burette, Suzanne Paradis, Dana Harrar, Sohail Tavazoie, Richard J Weinberg, Michael E Greenberg.
Abstract
NMDA-type glutamate receptors play a critical role in the activity-dependent development and structural remodeling of dendritic arbors and spines. However, the molecular mechanisms that link NMDA receptor activation to changes in dendritic morphology remain unclear. We report that the Rac1-GEF Tiam1 is present in dendrites and spines and is required for their development. Tiam1 interacts with the NMDA receptor and is phosphorylated in a calcium-dependent manner in response to NMDA receptor stimulation. Blockade of Tiam1 function with RNAi and dominant interfering mutants of Tiam1 suggests that Tiam1 mediates effects of the NMDA receptor on dendritic development by inducing Rac1-dependent actin remodeling and protein synthesis. Taken together, these findings define a molecular mechanism by which NMDA receptor signaling controls the growth and morphology of dendritic arbors and spines.Entities:
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Year: 2005 PMID： 15721239 DOI： 10.1016/j.neuron.2005.01.024
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173