Literature DB >> 1572075

Quantitative analysis of rat synaptosomes and cerebrum using high-resolution 1H magnetic resonance spectroscopy.

O A Petroff1, A P Burlina, J Black, J W Prichard.   

Abstract

This study explored the utility of 1H magnetic resonance spectroscopy to study a standard synaptosomally enriched preparation (P2 pellet) made from rat cerebrum. The preparation contained high concentrations of N-acetylaspartate and gamma-aminobutyric acid and low concentrations of glutamine, indicating that they were in fact rich in neuronal cytosol. Synaptosomes contained half the lactate and glutamine of cerebrum. Alanine, aspartate, glutamate, and succinate had the same concentrations in synaptosomes and cerebrum.

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Year:  1992        PMID: 1572075     DOI: 10.1016/0009-8981(92)90014-h

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN: 0009-8981            Impact factor:   3.786


  2 in total

1.  Metabolism of [1-13C]glucose in a synaptosomally enriched fraction of rat cerebrum studied by 1H/13C magnetic resonance spectroscopy.

Authors:  O A Petroff; A P Burlina; J Black; J W Prichard
Journal:  Neurochem Res       Date:  1991-11       Impact factor: 3.996

2.  Hypoosmolarity induces an increase of extracellular N-acetylaspartate concentration in the rat striatum.

Authors:  S E Davies; M Gotoh; D A Richards; T P Obrenovitch
Journal:  Neurochem Res       Date:  1998-08       Impact factor: 3.996

  2 in total

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