OBJECTIVE: The incidence of thromboembolism after colorectal surgery is higher than after general surgery. The aim of this paper is to update a systematic review addressing thrombosis prophylaxis in connection with colorectal surgery. METHODS: MEDLINE, EMBASE, LILACS, abstract books and reference lists from reviews were searched without language restrictions for randomized controlled trials or clinical controlled trials comparing prophylactic interventions and/or placebo up til August 2003. Five hundred and fifty-eight studies were identified of which 19 fulfilled the inclusion criteria. Data extraction was done by at least two of the authors. Outcome was deep venous thrombosis and/or pulmonary embolism diagnosed by various methods. RESULTS: Any kind of heparin is better than no treatment or placebo (11 studies) with a Peto Odds ratio (POR) at 0.32 (95% CI 0.20-0.53). Unfractionated heparin and low molecular weight heparin (4 studies) were equally effective POR 1.01 (95% CI 0.67-1.52). The combination of graduated compression stockings and LMWH is better than LMWH alone (2 studies) with a POR at 4.17 (95% CI 1.37-12.70). CONCLUSION: The optimal thromboprophylaxis in colorectal surgery is the combination of graduated compression stockings and low-dose unfractionated heparin or low molecular weight heparin.
OBJECTIVE: The incidence of thromboembolism after colorectal surgery is higher than after general surgery. The aim of this paper is to update a systematic review addressing thrombosis prophylaxis in connection with colorectal surgery. METHODS: MEDLINE, EMBASE, LILACS, abstract books and reference lists from reviews were searched without language restrictions for randomized controlled trials or clinical controlled trials comparing prophylactic interventions and/or placebo up til August 2003. Five hundred and fifty-eight studies were identified of which 19 fulfilled the inclusion criteria. Data extraction was done by at least two of the authors. Outcome was deep venous thrombosis and/or pulmonary embolism diagnosed by various methods. RESULTS: Any kind of heparin is better than no treatment or placebo (11 studies) with a Peto Odds ratio (POR) at 0.32 (95% CI 0.20-0.53). Unfractionated heparin and low molecular weight heparin (4 studies) were equally effective POR 1.01 (95% CI 0.67-1.52). The combination of graduated compression stockings and LMWH is better than LMWH alone (2 studies) with a POR at 4.17 (95% CI 1.37-12.70). CONCLUSION: The optimal thromboprophylaxis in colorectal surgery is the combination of graduated compression stockings and low-dose unfractionated heparin or low molecular weight heparin.
Authors: Paulus Menno Verheijen; Andrew R L Stevenson; Russel W Stitz; David A Clark; Andrew J Clark; John W Lumley Journal: Int J Colorectal Dis Date: 2011-01-27 Impact factor: 2.571
Authors: Song-Soo Yang; Chang Sik Yu; Yong Sik Yoon; Sang Nam Yoon; Seok-Byung Lim; Jin Cheon Kim Journal: World J Surg Date: 2011-04 Impact factor: 3.352
Authors: Christopher J Pannucci; Peter K Henke; Paul S Cederna; Shannon M Strachn; Sandra L Brown; Marc J Moote; Darrell A Campbell Journal: Am J Surg Date: 2011-07-23 Impact factor: 2.565
Authors: Charbel F Matar; Lara A Kahale; Maram B Hakoum; Ibrahim G Tsolakian; Itziar Etxeandia-Ikobaltzeta; Victor Ed Yosuico; Irene Terrenato; Francesca Sperati; Maddalena Barba; Holger Schünemann; Elie A Akl Journal: Cochrane Database Syst Rev Date: 2018-07-11
Authors: Dae Sik Kim; Keun-Myoung Park; Yong Sung Won; Jang Yong Kim; Jin Kwon Lee; Jun Gi Kim; Seong Taek Oh; Sang Seol Jung; Won Kyung Kang Journal: Vasc Specialist Int Date: 2014-06-30