Literature DB >> 15720112

Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen.

John R Jalas1, Stephen S Hecht, Sharon E Murphy.   

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Year:  2005        PMID: 15720112     DOI: 10.1021/tx049847p

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN: 0893-228X            Impact factor:   3.739


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  57 in total

1.  Transcriptional suppression of CYP2A13 expression by lipopolysaccharide in cultured human lung cells and the lungs of a CYP2A13-humanized mouse model.

Authors:  Hong Wu; Zhihua Liu; Guoyu Ling; David Lawrence; Xinxin Ding
Journal:  Toxicol Sci       Date:  2013-07-24       Impact factor: 4.849

2.  Analysis and Identification of 2'-Deoxyadenosine-Derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Authors:  Erik S Carlson; Pramod Upadhyaya; Peter W Villalta; Bin Ma; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2018-04-19       Impact factor: 3.739

3.  Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F-344 rats.

Authors:  Silvia Balbo; Charles S Johnson; Ramesh C Kovi; Sandra A James-Yi; M Gerard O'Sullivan; Mingyao Wang; Chap T Le; Samir S Khariwala; Pramod Upadhyaya; Stephen S Hecht
Journal:  Carcinogenesis       Date:  2014-09-30       Impact factor: 4.944

4.  Genetic variation affects congenital heart defect susceptibility in offspring exposed to maternal tobacco use.

Authors:  Xinyu Tang; Charlotte A Hobbs; Mario A Cleves; Stephen W Erickson; Stewart L MacLeod; Sadia Malik
Journal:  Birth Defects Res A Clin Mol Teratol       Date:  2015-06-02

5.  CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.

Authors:  Jian-Min Yuan; Heather H Nelson; Steven G Carmella; Renwei Wang; Jacquelyn Kuriger-Laber; Aizhen Jin; Jennifer Adams-Haduch; Stephen S Hecht; Woon-Puay Koh; Sharon E Murphy
Journal:  Carcinogenesis       Date:  2017-04-01       Impact factor: 4.944

6.  Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

Authors:  Xin Zhou; Jaime D'Agostino; Fang Xie; Xinxin Ding
Journal:  J Pharmacol Exp Ther       Date:  2012-01-19       Impact factor: 4.030

7.  Effect of CYP2A13 active site mutation N297A on metabolism of coumarin and tobacco-specific nitrosamines.

Authors:  Kari E Schlicht; Jeannette Zinggeler Berg; Sharon E Murphy
Journal:  Drug Metab Dispos       Date:  2008-12-12       Impact factor: 3.922

8.  Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.

Authors:  Jaime D'Agostino; Xiuling Zhang; Hong Wu; Guoyu Ling; Suping Wang; Qing-Yu Zhang; Fucai Liu; Xinxin Ding
Journal:  Drug Metab Dispos       Date:  2008-07-31       Impact factor: 3.922

9.  The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract.

Authors:  Jaime D'Agostino; Xiaoliang Zhuo; Mohammad Shadid; Daniel G Morgan; Xiuling Zhang; W Griffith Humphreys; Yue-Zhong Shu; Garold S Yost; Xinxin Ding
Journal:  Drug Metab Dispos       Date:  2009-07-16       Impact factor: 3.922

10.  Differential expression of microRNAs in early-stage neoplastic transformation in the lungs of F344 rats chronically treated with the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Authors:  Stephen Kalscheuer; Xiaoxiao Zhang; Yan Zeng; Pramod Upadhyaya
Journal:  Carcinogenesis       Date:  2008-09-09       Impact factor: 4.944

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