OBJECTIVE: To study the protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan (ALX) induced diabetic rats. METHOD: With the doses of polysaccharide of Spirulina platensis (PSP) and Sargassum thunbeergii (PST) compound (1:1) 12.261, 36.783, 110.349 mg x kg(-1) by i.g. administration to alloxan induced diabetic rats respectively for 6 weeks. Then the blood glucose and the TC, HDL-C, TG, NO, ET in serum were detected. The contraction and relaxation response to NE and ACh in aortic rings of the alloxan induced diabetic rats has been studied. RESULT: The results showed the compound of PSP and PST could decrease the blood glucose and the TC, TG, NO, ET in serum and increase HDL-C than in the alloxan induced diabetic rats. The contraction responses to NE in aortic rings of the alloxan induced diabetic rats were significantly elevated in the normal rats, and the responses to ACh were significantly lower. PSP and PST compound could significantly lower the responses to NE and significantly elevate the responses to ACh in aortic rings of the alloxan induced diabetic rats. CONCLUSION: PSP and PST compound could decrease blood glucose and could protect the vascular of alloxan induced diabetic rats.
OBJECTIVE: To study the protective effects of polysaccharide of Spirulina platensis and Sargassum thunbeergii on vascular of alloxan (ALX) induced diabeticrats. METHOD: With the doses of polysaccharide of Spirulina platensis (PSP) and Sargassum thunbeergii (PST) compound (1:1) 12.261, 36.783, 110.349 mg x kg(-1) by i.g. administration to alloxan induced diabeticrats respectively for 6 weeks. Then the blood glucose and the TC, HDL-C, TG, NO, ET in serum were detected. The contraction and relaxation response to NE and ACh in aortic rings of the alloxan induced diabeticrats has been studied. RESULT: The results showed the compound of PSP and PST could decrease the blood glucose and the TC, TG, NO, ET in serum and increase HDL-C than in the alloxan induced diabeticrats. The contraction responses to NE in aortic rings of the alloxan induced diabeticrats were significantly elevated in the normal rats, and the responses to ACh were significantly lower. PSP and PST compound could significantly lower the responses to NE and significantly elevate the responses to ACh in aortic rings of the alloxan induced diabeticrats. CONCLUSION:PSP and PST compound could decrease blood glucose and could protect the vascular of alloxan induced diabeticrats.
Authors: Aline de Freitas Brito; Alexandre S Silva; Alesandra A de Souza; Paula B Ferreira; Iara L L de Souza; Layanne C da Cunha Araujo; Gustavo da Silva Félix; Renata de Souza Sampaio; Maria da Conceição C Silva; Renata L Tavares; Reabias de Andrade Pereira; Manoel Miranda Neto; Bagnólia A da Silva Journal: Front Physiol Date: 2018-10-31 Impact factor: 4.566
Authors: Aline de Freitas Brito; Alexandre Sérgio Silva; Alesandra Araújo de Souza; Paula Benvindo Ferreira; Iara Leão Luna de Souza; Layanne Cabral da Cunha Araujo; Gustavo da Silva Félix; Renata de Souza Sampaio; Maria da Conceição Correia Silva; Renata Leite Tavares; Reabias de Andrade Pereira; Manoel Miranda Neto; Bagnólia Araújo Silva Journal: Oxid Med Cell Longev Date: 2019-10-24 Impact factor: 6.543
Authors: Layanne C C Araujo; Aline F Brito; Iara L L Souza; Paula B Ferreira; Luiz Henrique C Vasconcelos; Alexandre S Silva; Bagnólia A Silva Journal: Mar Drugs Date: 2020-01-29 Impact factor: 5.118