RATIONALE: Tobacco use and obesity lead to significant morbidity and mortality. OBJECTIVE: This study was conducted to investigate the factors maintaining smoking behavior in lean and obese individuals by utilizing a mouse/human cross-validation model of nicotine reward. METHODS: In humans, a cigarette choice paradigm was used to examine the relative reinforcing value of nicotine in obese and non-obese smokers. Conditioned place preference (CPP) for nicotine was assessed in mice fed standard low fat rodent chow and mice rendered obese by a high fat diet. RESULTS: In humans, obese smokers self-administered nicotine via cigarettes significantly less often than non-obese smokers and showed attenuated hedonic effects of nicotine-containing cigarettes compared to denicotinized cigarettes. Similarly, mice exposed to a high fat diet did not exhibit nicotine CPP, relative to control mice. mRNA levels for mu-opiate and leptin receptors were also downregulated in the ventral tegmental area of these mice. CONCLUSIONS: Together, these studies provide the first evidence for reduced nicotine reward in obese subjects and suggest that this may be mediated by dietary influences on the endogenous opioid system.
RATIONALE: Tobacco use and obesity lead to significant morbidity and mortality. OBJECTIVE: This study was conducted to investigate the factors maintaining smoking behavior in lean and obese individuals by utilizing a mouse/human cross-validation model of nicotine reward. METHODS: In humans, a cigarette choice paradigm was used to examine the relative reinforcing value of nicotine in obese and non-obese smokers. Conditioned place preference (CPP) for nicotine was assessed in mice fed standard low fat rodent chow and mice rendered obese by a high fat diet. RESULTS: In humans, obese smokers self-administered nicotine via cigarettes significantly less often than non-obese smokers and showed attenuated hedonic effects of nicotine-containing cigarettes compared to denicotinized cigarettes. Similarly, mice exposed to a high fat diet did not exhibit nicotine CPP, relative to control mice. mRNA levels for mu-opiate and leptin receptors were also downregulated in the ventral tegmental area of these mice. CONCLUSIONS: Together, these studies provide the first evidence for reduced nicotine reward in obese subjects and suggest that this may be mediated by dietary influences on the endogenous opioid system.
Authors: Margaret Rukstalis; Christopher Jepson; Andrew Strasser; Kevin G Lynch; Kenneth Perkins; Freda Patterson; Caryn Lerman Journal: Psychopharmacology (Berl) Date: 2005-01-29 Impact factor: 4.530
Authors: Dorothy K Hatsukami; Kenneth A Perkins; Mark G Lesage; David L Ashley; Jack E Henningfield; Neal L Benowitz; Cathy L Backinger; Mitch Zeller Journal: Tob Control Date: 2010-10 Impact factor: 7.552
Authors: Xiu Liu; Matthew I Palmatier; Anthony R Caggiula; Alan F Sved; Eric C Donny; Maysa Gharib; Sheri Booth Journal: Psychopharmacology (Berl) Date: 2008-09-21 Impact factor: 4.530
Authors: Francisco Ródenas-González; María Del Carmen Blanco-Gandía; María Pascual; Irene Molari; Consuelo Guerri; José Miñarro López; Marta Rodríguez-Arias Journal: Psychopharmacology (Berl) Date: 2021-03-31 Impact factor: 4.530
Authors: Melissa Mercincavage; Megan L Saddleson; Emily Gup; Angela Halstead; Darren Mays; Andrew A Strasser Journal: Drug Alcohol Depend Date: 2017-02-03 Impact factor: 4.492
Authors: Kenneth A Perkins; Caryn Lerman; Sarah Coddington; Christopher Jetton; Joshua L Karelitz; Annette Wilson; J Richard Jennings; Robert Ferrell; Andrew W Bergen; Neal L Benowitz Journal: Behav Pharmacol Date: 2008-09 Impact factor: 2.293