| Literature DB >> 15718848 |
Ferdinand Wnm Wit1, Daniel H Blanckenberg, Kees Brinkman, Jan M Prins, Marchina E van der Ende, Margriet Me Schneider, Jan-Willem Mulder, Frank de Wolf, Joep Ma Lange.
Abstract
We studied the dynamics of CD4 cell counts after the interruption of virologically successful highly active antiretroviral therapy (HAART) in 139 patients. Changes in CD4 cell counts during HAART interruption followed a biphasic pattern: an initial rapid decline during the first month followed by a slow decrease. During 48 weeks of follow-up mean CD4 cell counts remained just above the mean pre-HAART level. This limits the feasibility of structured treatment interruptions for patients with low nadir CD4 cell counts.Entities:
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Year: 2005 PMID： 15718848
Source DB: PubMed Journal: AIDS ISSN： 0269-9370 Impact factor: 4.177