R Mottl1, J Cerman. 1. Klinika gerontologická a metabolická Lékarské fakulty UK a FN, Hradec Králové.
Abstract
UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormone dehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive. METHODS: In our study participated 50 obese women and 20 obese men both with BMI over 27 kg/m2. Insulin resistance was calculated using HOMA insulin resistance index (HOMA-IR) that is based on fasting glycaemia and basal insulin levels. RESULTS: The negative correlation between DHEAS and HOMA-IR was found in the whole group of obese women but close behind statistical significance (r = -0.27, p = 0.055). But the group of obese women does not seem to be homogenous in correlation between DHEAS and insulin resistance. The significant negative correlation between DHEAS and insulin resistance was found in the subgroup (n = 21) of obese type 2 diabetic women (r = -0.55, p = 0.01) but no correlation was found in the subgroup (n = 29) of obese non-diabetic women (r = -0.06, p = 0.77). The relationship between DHEAS and glycaemia homeostasis was also confirmed by significant negative correlation between DHEAS and glycated haemoglobin (HbA1c) both in the subgroup of type 2 diabetic women (r = -0.51, p = 0.03) and in the subgroup of non-diabetic women (r = -0.70, p = 0.001). There was not found any significant correlation between DHEAS and insulin resistance neither in the whole group (n = 20) of obese men (r = 0.04, p = 0.87) nor in the subgroup (n = 11) of obese type 2 diabetic men (r = 0.55, p = 0.08) or in the subgroup (n = 9) of obese non-diabetic men (r = -0.42, p = 0.26). CONCLUSIONS: Significant negative correlation between DHEAS and HOMA-IR was found in the group of obese type 2 diabetic women but not in obese non-diabetic women suggesting that low DHEAS level might be connected to the development of insulin resistance and type 2 diabetes mellitus in obese women.
UNLABELLED: The aim of our study was to investigate if there is any significant relationship between adrenal steroid hormonedehydroepiandrosterone-sulphate (DHEAS) and insulin resistance, as there are some previous signs in the literature suggesting such relationship but the results are not conclusive. METHODS: In our study participated 50 obesewomen and 20 obesemen both with BMI over 27 kg/m2. Insulin resistance was calculated using HOMA insulin resistance index (HOMA-IR) that is based on fasting glycaemia and basal insulin levels. RESULTS: The negative correlation between DHEAS and HOMA-IR was found in the whole group of obesewomen but close behind statistical significance (r = -0.27, p = 0.055). But the group of obesewomen does not seem to be homogenous in correlation between DHEAS and insulin resistance. The significant negative correlation between DHEAS and insulin resistance was found in the subgroup (n = 21) of obese type 2 diabeticwomen (r = -0.55, p = 0.01) but no correlation was found in the subgroup (n = 29) of obese non-diabeticwomen (r = -0.06, p = 0.77). The relationship between DHEAS and glycaemia homeostasis was also confirmed by significant negative correlation between DHEAS and glycated haemoglobin (HbA1c) both in the subgroup of type 2 diabeticwomen (r = -0.51, p = 0.03) and in the subgroup of non-diabeticwomen (r = -0.70, p = 0.001). There was not found any significant correlation between DHEAS and insulin resistance neither in the whole group (n = 20) of obesemen (r = 0.04, p = 0.87) nor in the subgroup (n = 11) of obese type 2 diabeticmen (r = 0.55, p = 0.08) or in the subgroup (n = 9) of obese non-diabeticmen (r = -0.42, p = 0.26). CONCLUSIONS: Significant negative correlation between DHEAS and HOMA-IR was found in the group of obese type 2 diabeticwomen but not in obese non-diabeticwomen suggesting that low DHEAS level might be connected to the development of insulin resistance and type 2 diabetes mellitus in obesewomen.
Authors: Guangju Zhai; Alexander Teumer; Lisette Stolk; John R B Perry; Liesbeth Vandenput; Andrea D Coviello; Annemarie Koster; Jordana T Bell; Shalender Bhasin; Joel Eriksson; Anna Eriksson; Florian Ernst; Luigi Ferrucci; Timothy M Frayling; Daniel Glass; Elin Grundberg; Robin Haring; Asa K Hedman; Albert Hofman; Douglas P Kiel; Heyo K Kroemer; Yongmei Liu; Kathryn L Lunetta; Marcello Maggio; Mattias Lorentzon; Massimo Mangino; David Melzer; Iva Miljkovic; Alexandra Nica; Brenda W J H Penninx; Ramachandran S Vasan; Fernando Rivadeneira; Kerrin S Small; Nicole Soranzo; André G Uitterlinden; Henry Völzke; Scott G Wilson; Li Xi; Wei Vivian Zhuang; Tamara B Harris; Joanne M Murabito; Claes Ohlsson; Anna Murray; Frank H de Jong; Tim D Spector; Henri Wallaschofski Journal: PLoS Genet Date: 2011-04-14 Impact factor: 5.917