BACKGROUND: The genetic relatedness of hepatitis A virus (HAV) isolates was determined to identify possible infection sources for case patients in the Sentinel Counties Study of Acute Viral Hepatitis. METHODS: A 315-nucleotide segment of the VP1-P2 region of the HAV genome was amplified and sequenced from serum of case patients and analyzed together with risk-factor data. RESULTS: Of 508 HAV-RNA-positive case patients, 449 (88.4%) were interviewed, and 255 (50.1%) reported >/=1 risk factor. Some 123 unique nucleotide sequence patterns (UNSPs) were identified--77 (62.6%) from only 1 case patient and the rest in 2-99 persons. Among international travelers, a single person was more often infected with a single type of UNSP (17/54 [31.5%]), compared with other case patients (48/393 [12.2%]; P<.001). UNSPs from travelers to Mexico (33/37 [89.2%]) clustered with those from Hispanic children (47/49 [95.9%]). Of 119 men who had sex with men, 96 (80.7%) had the same or similar UNSPs, which were also found in 37 men and 10 women with no identified infection source. CONCLUSION: HAV is often transmitted within networks of persons with similar risk factors, which may be the infection source for others in the community.
BACKGROUND: The genetic relatedness of hepatitis A virus (HAV) isolates was determined to identify possible infection sources for case patients in the Sentinel Counties Study of Acute Viral Hepatitis. METHODS: A 315-nucleotide segment of the VP1-P2 region of the HAV genome was amplified and sequenced from serum of case patients and analyzed together with risk-factor data. RESULTS: Of 508 HAV-RNA-positive case patients, 449 (88.4%) were interviewed, and 255 (50.1%) reported >/=1 risk factor. Some 123 unique nucleotide sequence patterns (UNSPs) were identified--77 (62.6%) from only 1 case patient and the rest in 2-99 persons. Among international travelers, a single person was more often infected with a single type of UNSP (17/54 [31.5%]), compared with other case patients (48/393 [12.2%]; P<.001). UNSPs from travelers to Mexico (33/37 [89.2%]) clustered with those from Hispanic children (47/49 [95.9%]). Of 119 men who had sex with men, 96 (80.7%) had the same or similar UNSPs, which were also found in 37 men and 10 women with no identified infection source. CONCLUSION:HAV is often transmitted within networks of persons with similar risk factors, which may be the infection source for others in the community.
Authors: K Schenkel; V Bremer; C Grabe; U Van Treeck; E Schreier; M Höhne; A Ammon; K Alpers Journal: Epidemiol Infect Date: 2006-05-02 Impact factor: 2.451
Authors: Philip R Spradling; Jian Xing; Alba Phippard; Maureen Fonseca-Ford; Sonia Montiel; Norma Luna Guzmán; Roberto Vázquez Campuzano; Gilberto Vaughan; Guo-liang Xia; Jan Drobeniuc; Saleem Kamili; Ricardo Cortés-Alcalá; Stephen H Waterman Journal: J Immigr Minor Health Date: 2013-04
Authors: V Ajmera; G Xia; G Vaughan; J C Forbi; L M Ganova-Raeva; Y Khudyakov; C K Opio; R Taylor; R Restrepo; S Munoz; R J Fontana; W M Lee Journal: J Viral Hepat Date: 2010-12-08 Impact factor: 3.728
Authors: Ryan M Taylor; Timothy Davern; Santiago Munoz; Stephen-Huy Han; Brendan McGuire; Anne M Larson; Linda Hynan; William M Lee; Robert J Fontana Journal: Hepatology Date: 2006-12 Impact factor: 17.425
Authors: Alexandra Tejada-Strop; Mohammad Zafrullah; Saleem Kamili; Susan L Stramer; Michael A Purdy Journal: Transfusion Date: 2018-10-04 Impact factor: 3.157
Authors: Christina Frank; Jan Walter; Marion Muehlen; Andreas Jansen; Ulrich van Treeck; Anja M Hauri; Iris Zoellner; Magda Rakha; Marina Hoehne; Osamah Hamouda; Eckart Schreier; Klaus Stark Journal: Emerg Infect Dis Date: 2007-01 Impact factor: 6.883
Authors: Noele P Nelson; Mark K Weng; Megan G Hofmeister; Kelly L Moore; Mona Doshani; Saleem Kamili; Alaya Koneru; Penina Haber; Liesl Hagan; José R Romero; Sarah Schillie; Aaron M Harris Journal: MMWR Recomm Rep Date: 2020-07-03