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Literature DB >> 15717049

Positron emission tomography imaging of transplant function.

Abstract

In this article, the role of functional imaging for providing objective evidence that grafts of fetal tissue can survive and form connections in Parkinson's and Huntington's disease patients is reviewed. The dissociation between dopamine storage capacity, clinical improvement, and normalization of brain metabolism in PD is discussed, and possible mechanisms underlying the phenomenon of dyskinesias off medication are presented. It is concluded the positron emission tomography and single photon emission computed tomography can provide valuable ancillary information alongside clinical observations but are not currently appropriate modalities for use as surrogate endpoints.

Entities: Chemical Disease Species

Mesh：

Substances：
Dopamine

Year: 2004 PMID： 15717049 PMCID： PMC534954 DOI： 10.1602/neurorx.1.4.482

Source DB: PubMed Journal: NeuroRx ISSN： 1545-5343

77 in total

1. Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects.

Authors: M Jahanshahi; I H Jenkins; R G Brown; C D Marsden; R E Passingham; D J Brooks
Journal: Brain Date: 1995-08 Impact factor: 13.501

2. Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies.

Authors: J H Kordower; J M Rosenstein; T J Collier; M A Burke; E Y Chen; J M Li; L Martel; A E Levey; E J Mufson; T B Freeman; C W Olanow
Journal: J Comp Neurol Date: 1996-06-24 Impact factor: 3.215

3. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease.

Authors: J H Kordower; T B Freeman; B J Snow; F J Vingerhoets; E J Mufson; P R Sanberg; R A Hauser; D A Smith; G M Nauert; D P Perl
Journal: N Engl J Med Date: 1995-04-27 Impact factor: 91.245

3. Optimizing functional imaging protocols for assessing the outcome of fetal cell transplantation in Parkinson's disease.

Authors: Marios Politis
Journal: BMC Med Date: 2011-05-10 Impact factor: 8.775

Review 4. MR-based imaging of neural stem cells.

Authors: Letterio S Politi
Journal: Neuroradiology Date: 2007-03-08 Impact factor: 2.995

4 in total

Positron emission tomography imaging of transplant function.

1. Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects.

2. Functional fetal nigral grafts in a patient with Parkinson's disease: chemoanatomic, ultrastructural, and metabolic studies.

3. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease.

4. Assessment of striatal graft viability in the rat in vivo using a small diameter PET scanner.

5. Clinical correlates of [18F]fluorodopa uptake in five grafted parkinsonian patients.

6. [123I] beta-CIT/SPECT imaging demonstrates bilateral loss of dopamine transporters in hemi-Parkinson's disease.

7. Striatal D1 and D2 dopamine receptor loss in asymptomatic mutation carriers of Huntington's disease.

8. Striatal D1 and D2 receptor binding in patients with Huntington's disease and other choreas. A PET study.

9. Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease.

10. SPECT imaging of striatal dopamine release after amphetamine challenge.

1. Molecular imaging of cell transplantation in Parkinson's disease.

2. Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys.

3. Optimizing functional imaging protocols for assessing the outcome of fetal cell transplantation in Parkinson's disease.

Review 4. MR-based imaging of neural stem cells.