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Literature DB >> 15717044

Cell therapy for stroke.

Sean I Savitz¹, Jonathan H Dinsmore, Lawrence R Wechsler, Daniel M Rosenbaum, Louis R Caplan.

Abstract

Increasing experimental evidence suggests that cell transplantation can enhance recovery from stroke in animal models of focal cerebral ischemia. Clinical trials have been investigating the effects of a human immortalized neuronal cell line and porcine fetal neurons in stroke victims with persistent and stable deficits. Preclinical studies are focusing on the effects of human stem cells from various sources including brain, bone marrow, umbilical cord, and adipose tissue. This review presents an overview of preclinical and clinical studies on cell therapy for stroke. We emphasize the current, limited knowledge about the biology of implant sources and discuss special conditions in stroke that will impact the potential success of neurotransplantation in clinical trials.

Entities: Disease Species

Mesh：

Year: 2004 PMID： 15717044 PMCID： PMC534949 DOI： 10.1602/neurorx.1.4.406

Source DB: PubMed Journal: NeuroRx ISSN： 1545-5343

46 in total

Review 1. Mechanisms, challenges and opportunities in stroke.

Authors: Eng H Lo; Turgay Dalkara; Michael A Moskowitz
Journal: Nat Rev Neurosci Date: 2003-05 Impact factor: 34.870

2. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors.

Authors: Hirofumi Nakatomi; Toshihiko Kuriu; Shigeo Okabe; Shin-ichi Yamamoto; Osamu Hatano; Nobutaka Kawahara; Akira Tamura; Takaaki Kirino; Masato Nakafuku
Journal: Cell Date: 2002-08-23 Impact factor: 41.582

3. Cell proliferation and differentiation from ependymal, subependymal and choroid plexus cells in response to stroke in rats.

Authors: Yi Li; Jieli Chen; Michael Chopp
Journal: J Neurol Sci Date: 2002-01-15 Impact factor: 3.181

4. Surface protein characterization of human adipose tissue-derived stromal cells.

Authors: S Gronthos; D M Franklin; H A Leddy; P G Robey; R W Storms; J M Gimble
Journal: J Cell Physiol Date: 2001-10 Impact factor: 6.384

5. Long-term survival of fetal porcine lateral ganglionic eminence cells in the hippocampus of rats.

Authors: D B Jacoby; C Lindberg; M G Cunningham; J Ratliff; J Dinsmore
Journal: J Neurosci Res Date: 1999-06-15 Impact factor: 4.164

6. Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation.

Authors: Peter T Nelson; Douglas Kondziolka; Lawrence Wechsler; Steven Goldstein; James Gebel; Sharon DeCesare; Elaine M Elder; Paul J Zhang; Alan Jacobs; Michael McGrogan; Virginia M-Y Lee; John Q Trojanowski
Journal: Am J Pathol Date: 2002-04 Impact factor: 4.307

7. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats.

Authors: Jieli Chen; Zheng Gang Zhang; Yi Li; Lei Wang; Yong Xian Xu; Subhash C Gautam; Mei Lu; Zhenping Zhu; Michael Chopp
Journal: Circ Res Date: 2003-02-27 Impact factor: 17.367

8. Neuronal replacement from endogenous precursors in the adult brain after stroke.

Authors: Andreas Arvidsson; Tove Collin; Deniz Kirik; Zaal Kokaia; Olle Lindvall
Journal: Nat Med Date: 2002-08-05 Impact factor: 53.440

9. Stem cell-derived cardiomyocytes demonstrate arrhythmic potential.

Authors: Ying Ming Zhang; Criss Hartzell; Michael Narlow; Samuel C Dudley
Journal: Circulation Date: 2002-09-03 Impact factor: 29.690

10. Ischemic rat brain extracts induce human marrow stromal cell growth factor production.

Authors: Xiaoguang Chen; Yi Li; Lei Wang; Mark Katakowski; Lijie Zhang; Jieli Chen; Yongxian Xu; Subhash C Gautam; Michael Chopp
Journal: Neuropathology Date: 2002-12 Impact factor: 1.906

24 in total

Review 1. Neuroprotection for ischemic stroke: past, present and future.

Authors: Myron D Ginsberg
Journal: Neuropharmacology Date: 2008-03-04 Impact factor: 5.250

2. Composite MR Contrast Agents for Conditional Cell-Labeling.

Authors: Matthew Marzelli; Krisztina Fischer; Young Beom Kim; Robert V Mulkern; Seung-Schik Yoo; Hyunwook Park; Zang-Hee Cho
Journal: Int J Imaging Syst Technol Date: 2008-06-13 Impact factor: 2.000

3. Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study.

Authors: Lian Li; Quan Jiang; Guangliang Ding; Li Zhang; Zheng Gang Zhang; Qingjiang Li; Swayamprava Panda; Mei Lu; James R Ewing; Michael Chopp
Journal: J Cereb Blood Flow Metab Date: 2009-11-04 Impact factor: 6.200

Cell therapy for stroke.

Review 1. Mechanisms, challenges and opportunities in stroke.

2. Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors.

3. Cell proliferation and differentiation from ependymal, subependymal and choroid plexus cells in response to stroke in rats.

4. Surface protein characterization of human adipose tissue-derived stromal cells.

5. Long-term survival of fetal porcine lateral ganglionic eminence cells in the hippocampus of rats.

6. Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation.

7. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats.

8. Neuronal replacement from endogenous precursors in the adult brain after stroke.

9. Stem cell-derived cardiomyocytes demonstrate arrhythmic potential.

10. Ischemic rat brain extracts induce human marrow stromal cell growth factor production.

Review 1. Neuroprotection for ischemic stroke: past, present and future.

2. Composite MR Contrast Agents for Conditional Cell-Labeling.

3. Effects of administration route on migration and distribution of neural progenitor cells transplanted into rats with focal cerebral ischemia, an MRI study.

Review 4. Neurorestorative treatment of stroke: cell and pharmacological approaches.

Review 5. Is Immunomodulation a Principal Mechanism Underlying How Cell-Based Therapies Enhance Stroke Recovery?

Review 6. Stem cell therapies in age-related neurodegenerative diseases and stroke.

7. Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells.

8. Hematopoietic stem cell transplantation protects mice from lethal stroke.

9. Intra-arterial injection of neural stem cells using a microneedle technique does not cause microembolic strokes.

Review 10. Stem cells: implications in experimental ischaemic stroke therapy.