AIMS: Late after total correction, Fallot patients with a long QRS duration are prone to serious arrhythmias and sudden cardiac death. Pulmonary regurgitation is a common cause of right ventricular (RV) failure and QRS lengthening. We studied the effects of pulmonary valve replacement (PVR) on QRS duration and RV volume. METHODS AND RESULTS: Twenty-six consecutive Fallot patients were evaluated both pre-operatively and 6-12 months post-operatively by cardiac magnetic resonance (CMR). In this study, we present the computer-assisted analysis of the standard 12-lead electrocardiograms closest in time to the CMR studies. For the whole group, QRS duration shortened by 6+/-8 ms, from 151+/-30 to 144+/-29 ms (P=0.002). QRS duration decreased in 18 of 26 patients by 10+/-6 ms, from 152+/-32 to 142+/-31 ms. QRS duration remained constant or increased slightly in eight of 26 patients by 3+/-3 ms, from 148+/-27 to 151+/-25 ms. CMR showed a decrease in RV end-diastolic volume from 305+/-87 to 210+/-62 mL (P=0.000004). QRS duration changes correlated with RV end-diastolic volume changes (r=0.54, P=0.01). CONCLUSION: Our study shows that PVR reduces QRS duration. The amount of QRS reduction is related to the success of the operation, as expressed by the reduction in RV end-diastolic volume.
AIMS: Late after total correction, Fallot patients with a long QRS duration are prone to serious arrhythmias and sudden cardiac death. Pulmonary regurgitation is a common cause of right ventricular (RV) failure and QRS lengthening. We studied the effects of pulmonary valve replacement (PVR) on QRS duration and RV volume. METHODS AND RESULTS: Twenty-six consecutive Fallot patients were evaluated both pre-operatively and 6-12 months post-operatively by cardiac magnetic resonance (CMR). In this study, we present the computer-assisted analysis of the standard 12-lead electrocardiograms closest in time to the CMR studies. For the whole group, QRS duration shortened by 6+/-8 ms, from 151+/-30 to 144+/-29 ms (P=0.002). QRS duration decreased in 18 of 26 patients by 10+/-6 ms, from 152+/-32 to 142+/-31 ms. QRS duration remained constant or increased slightly in eight of 26 patients by 3+/-3 ms, from 148+/-27 to 151+/-25 ms. CMR showed a decrease in RV end-diastolic volume from 305+/-87 to 210+/-62 mL (P=0.000004). QRS duration changes correlated with RV end-diastolic volume changes (r=0.54, P=0.01). CONCLUSION: Our study shows that PVR reduces QRS duration. The amount of QRS reduction is related to the success of the operation, as expressed by the reduction in RV end-diastolic volume.
Authors: Martial M Massin; Sophie G Malekzadeh-Milani; Stefan Schifflers; Hugues Dessy; Thierry Verbeet Journal: Ann Noninvasive Electrocardiol Date: 2011-10 Impact factor: 1.468
Authors: Thomas Oosterhof; Hubert W Vliegen; Folkert J Meijboom; Aeilko H Zwinderman; Berto Bouma; Barbara J M Mulder Journal: Heart Date: 2006-10-25 Impact factor: 5.994
Authors: M Grothoff; B Spors; H Abdul-Khaliq; M Abd El Rahman; V Alexi-Meskishvili; P Lange; R Felix; M Gutberlet Journal: Clin Res Cardiol Date: 2006-10-10 Impact factor: 5.460
Authors: Michael L O'Byrne; Andrew C Glatz; Laura Mercer-Rosa; Matthew J Gillespie; Yoav Dori; Elizabeth Goldmuntz; Steven Kawut; Jonathan J Rome Journal: Am J Cardiol Date: 2014-10-16 Impact factor: 2.778
Authors: David M Harrild; Charles I Berul; Frank Cecchin; Tal Geva; Kimberlee Gauvreau; Frank Pigula; Edward P Walsh Journal: Circulation Date: 2009-01-12 Impact factor: 29.690