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Literature DB >> 15715974

Lipid rafts and their roles in T-cell activation.

Abstract

Lipid rafts are defined as detergent-resistant membrane microdomains of specific lipid and protein composition. They are involved in many aspects of cell biology, including T-cell activation and immunoreceptor signaling. This review discusses current controversies around lipid rafts and summarizes recent developments in the area.

Entities: Chemical

Mesh：

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Year: 2005 PMID： 15715974 DOI： 10.1016/j.micinf.2004.12.004

Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700

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Cited

12 in total

Review 1. Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation.

Authors: Anne K Kenworthy
Journal: EMBO Rep Date: 2008-06 Impact factor: 8.807

2. T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

Authors: Boryana N Manz; Bryan L Jackson; Rebecca S Petit; Michael L Dustin; Jay Groves
Journal: Proc Natl Acad Sci U S A Date: 2011-05-16 Impact factor: 11.205

3. L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration.

Authors: Esther Serrano-Pertierra; Eva Cernuda-Morollón; Tomáš Brdička; Václav Hoøejši; Carlos López-Larrea
Journal: J Leukoc Biol Date: 2014-05-06 Impact factor: 4.962

4. Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain.

Authors: Chitose Oneyama; Takuya Iino; Kazunobu Saito; Kei Suzuki; Akira Ogawa; Masato Okada
Journal: Mol Cell Biol Date: 2009-10-12 Impact factor: 4.272

5. Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development.

Authors: Teresa Cejalvo; Rosa Sacedón; Carmen Hernández-López; Blanca Diez; Cruz Gutierrez-Frías; Jaris Valencia; Agustín G Zapata; Alberto Varas; Angeles Vicente
Journal: Immunology Date: 2007-05 Impact factor: 7.397

Lipid rafts and their roles in T-cell activation.

Review 1. Have we become overly reliant on lipid rafts? Talking Point on the involvement of lipid rafts in T-cell activation.

2. T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

3. L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration.

4. Transforming potential of Src family kinases is limited by the cholesterol-enriched membrane microdomain.

5. Bone morphogenetic protein-2/4 signalling pathway components are expressed in the human thymus and inhibit early T-cell development.

Review 6. Receptor signaling clusters in the immune synapse.

Review 7. Mechanisms for T cell receptor triggering.

Review 8. TCR Signaling: Mechanisms of Initiation and Propagation.

9. Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response.

10. The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1.