| Literature DB >> 15715498 |
Albert C Pierce1, Ernst ter Haar, Hayley M Binch, David P Kay, Sanjay R Patel, Pan Li.
Abstract
Aryl CH hydrogen bonds play an important role in the binding of several analogues of a pyrazol-3-ylquinazolin-4-ylamine inhibitor of glycogen synthase kinase 3 (GSK3). Understanding the importance of these CH...O and CH...N hydrogen bonds allowed the design of a novel quinazolin-4-ylthiazol-2-ylamine inhibitor of GSK3 with a structurally confirmed CH...O hydrogen bond to the protein.Entities:
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Year: 2005 PMID： 15715498 DOI： 10.1021/jm0492249
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446