Literature DB >> 15713421

(E)-Phenyl- and -heteroaryl-substituted O-benzoyl-(or acyl)oximes as lipoprotein-associated phospholipase A2 inhibitors.

Tae-Sook Jeong1, Mi Jeong Kim, Hana Yu, Kyung Soon Kim, Joong-Kwon Choi, Sung-Soo Kim, Woo Song Lee.   

Abstract

A series of (E)-phenyl- and -heteroaryl-substituted O-benzoyl- (or acyl)oximes 3a-n were synthesized for evaluating their human lipoprotein-associated phospholiphase A2 (Lp-PLA2) inhibitory activities. The less lipophilic derivatives 3a-c showed the most potent in vitro inhibitory activity on human Lp-PLA2.

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Year:  2005        PMID： 15713421     DOI： 10.1016/j.bmcl.2004.11.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Effects of A379V variant of the Lp-PLA 2 gene on Lp-PLA 2 activity and markers of oxidative stress and endothelial function in Koreans.

Authors:  Jey Sook Chae; Jung Hyun Kwak; Minjoo Kim; Kyoung Hun Shin; Sang-Hyun Lee; Tae-Sook Jeong; Jong Ho Lee
Journal:  J Thromb Thrombolysis       Date:  2014-11       Impact factor: 2.300

Review 2.  Lipoprotein-associated phospholipase A2: The story continues.

Authors:  Fubao Huang; Kai Wang; Jianhua Shen
Journal:  Med Res Rev       Date:  2019-05-29       Impact factor: 12.944

3.  Beckmann Rearrangement of Ketoxime Catalyzed by N-methyl-imidazolium Hydrosulfate.

Authors:  Hongyu Hu; Xuting Cai; Zhuying Xu; Xiaoyang Yan; Shengxian Zhao
Journal:  Molecules       Date:  2018-07-18       Impact factor: 4.411

Review 4.  pCRP-mCRP Dissociation Mechanisms as Potential Targets for the Development of Small-Molecule Anti-Inflammatory Chemotherapeutics.

Authors:  Vittorio Caprio; Lina Badimon; Mario Di Napoli; Wen-Hui Fang; Glenn R Ferris; Baoqiang Guo; Rocco S Iemma; Donghui Liu; Yasmin Zeinolabediny; Mark Slevin
Journal:  Front Immunol       Date:  2018-05-28       Impact factor: 7.561
  4 in total

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