Literature DB >> 15713406

Synthesis and evaluation of azalanstat analogues as heme oxygenase inhibitors.

Jason Z Vlahakis1, Robert T Kinobe, Raymond J Bowers, James F Brien, Kanji Nakatsu, Walter A Szarek.   

Abstract

Several analogues based on the lead structure of azalanstat were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). A number of these compounds, which are structurally distinct from metalloporphyrin HO inhibitors, were found to be selective for the HO-1 isozyme (stress induced), and had substantially less inhibitory activity on HO-2, the constitutive isozyme.

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Year:  2005        PMID： 15713406     DOI： 10.1016/j.bmcl.2004.12.075

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Structural insights into human heme oxygenase-1 inhibition by potent and selective azole-based compounds.

Authors:  Mona N Rahman; Dragic Vukomanovic; Jason Z Vlahakis; Walter A Szarek; Kanji Nakatsu; Zongchao Jia
Journal:  J R Soc Interface       Date:  2012-11-08       Impact factor: 4.118

2.  Selectivity of imidazole-dioxolane compounds for in vitro inhibition of microsomal haem oxygenase isoforms.

Authors:  Robert T Kinobe; Jason Z Vlahakis; Hendrik J Vreman; David K Stevenson; James F Brien; Walter A Szarek; Kanji Nakatsu
Journal:  Br J Pharmacol       Date:  2006-02       Impact factor: 8.739

Review 3.  Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation.

Authors:  Stefan W Ryter; Augustine M K Choi
Journal:  Transl Res       Date:  2015-06-23       Impact factor: 7.012

Review 4.  Metalloporphyrins in the management of neonatal hyperbilirubinemia.

Authors:  David K Stevenson; Ronald J Wong
Journal:  Semin Fetal Neonatal Med       Date:  2009-12-16       Impact factor: 3.926

5.  Isocyanides inhibit human heme oxygenases at the verdoheme stage.

Authors:  John P Evans; Sylvie Kandel; Paul R Ortiz de Montellano
Journal:  Biochemistry       Date:  2009-09-22       Impact factor: 3.162

6.  A novel, "double-clamp" binding mode for human heme oxygenase-1 inhibition.

Authors:  Mona N Rahman; Jason Z Vlahakis; Dragic Vukomanovic; Wallace Lee; Walter A Szarek; Kanji Nakatsu; Zongchao Jia
Journal:  PLoS One       Date:  2012-01-19       Impact factor: 3.240

7.  Curcumin-induced heme oxygenase-1 expression prevents H2O2-induced cell death in wild type and heme oxygenase-2 knockout adipose-derived mesenchymal stem cells.

Authors:  Niels A J Cremers; Ditte M S Lundvig; Stephanie C M van Dalen; Rik F Schelbergen; Peter L E M van Lent; Walter A Szarek; Raymond F Regan; Carine E Carels; Frank A D T G Wagener
Journal:  Int J Mol Sci       Date:  2014-10-08       Impact factor: 5.923

Review 8.  Clinical Significance of Heme Oxygenase 1 in Tumor Progression.

Authors:  Mariapaola Nitti; Caterina Ivaldo; Nicola Traverso; Anna Lisa Furfaro
Journal:  Antioxidants (Basel)       Date:  2021-05-17

9.  Curcumin-induced fibroblast apoptosis and in vitro wound contraction are regulated by antioxidants and heme oxygenase: implications for scar formation.

Authors:  A Scharstuhl; H A M Mutsaers; S W C Pennings; W A Szarek; F G M Russel; F A D T G Wagener
Journal:  J Cell Mol Med       Date:  2008-04-10       Impact factor: 5.310

10.  In vitro Activation of heme oxygenase-2 by menadione and its analogs.

Authors:  Dragic Vukomanovic; Mona N Rahman; Yaroslav Bilokin; Andriy G Golub; James F Brien; Walter A Szarek; Zongchao Jia; Kanji Nakatsu
Journal:  Med Gas Res       Date:  2014-02-18
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