| Literature DB >> 15713403 |
Christopher W Plummer1, Paul E Finke, Sander G Mills, Junying Wang, Xinchun Tong, George A Doss, Tung M Fong, Julie Z Lao, Marie-Therese Schaeffer, Jing Chen, Chun-Pyn Shen, D Sloan Stribling, Lauren P Shearman, Alison M Strack, Lex H T Van der Ploeg.
Abstract
Structure-activity relationship studies directed toward the optimization of 4,5-diarylimidazole-2-carboxamide analogs as human CB1 receptor inverse agonists resulted in the discovery of the two amide derivatives 24a and b (hCB1 IC50 = 6.1 and 4.0 nM) which also demonstrated efficacy in overnight feeding studies in the rat for reduction in both food intake and overall body weight.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15713403 DOI： 10.1016/j.bmcl.2004.12.078
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823