Literature DB >> 15713393

Chemistry and biology of mercaptoacetamides as novel histone deacetylase inhibitors.

Bin Chen1, Pavel A Petukhov, Mira Jung, Alfredo Velena, Elena Eliseeva, Anatoly Dritschilo, Alan P Kozikowski.   

Abstract

A series of mercaptoacetamides were designed and synthesized as novel histone deacetylase inhibitors with the aid of modeling. Their ability to inhibit HDAC activity and their effects on cancer cell growth were investigated. Some compounds exhibit better HDAC inhibitory activity than SAHA.

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Year:  2005        PMID： 15713393     DOI： 10.1016/j.bmcl.2005.01.006

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

1.  Thiol-Based Potent and Selective HDAC6 Inhibitors Promote Tubulin Acetylation and T-Regulatory Cell Suppressive Function.

Authors:  Mariana C F Segretti; Gian Paolo Vallerini; Camille Brochier; Brett Langley; Liqing Wang; Wayne W Hancock; Alan P Kozikowski
Journal:  ACS Med Chem Lett       Date:  2015-10-05       Impact factor: 4.345

2.  Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.

Authors:  Irina V Getun; Zhen Wu; Mohammad Fallahi; Souad Ouizem; Qin Liu; Weimin Li; Roberta Costi; William R Roush; John L Cleveland; Philippe R J Bois
Journal:  Mol Cell Biol       Date:  2017-01-19       Impact factor: 4.272

Review 3.  Histone deacetylase inhibitor: antineoplastic agent and radiation modulator.

Authors:  Zacharoula Konsoula; Alfredo Velena; Rachel Lee; Anatoly Dritschilo; Mira Jung
Journal:  Adv Exp Med Biol       Date:  2011       Impact factor: 2.622

4.  Histone deacetylase cytoplasmic trapping by a novel fluorescent HDAC inhibitor.

Authors:  Yali Kong; Mira Jung; Kan Wang; Scott Grindrod; Alfredo Velena; Sung A Lee; Sivanesan Dakshanamurthy; Yonghong Yang; Matthew Miessau; Chaoyi Zheng; Anatoly Dritschilo; Milton L Brown
Journal:  Mol Cancer Ther       Date:  2011-06-22       Impact factor: 6.261

5.  In vitro plasma stability, permeability and solubility of mercaptoacetamide histone deacetylase inhibitors.

Authors:  Roula Konsoula; Mira Jung
Journal:  Int J Pharm       Date:  2008-05-13       Impact factor: 5.875

6.  HDAC inhibitor increases histone H3 acetylation and reduces microglia inflammatory response following traumatic brain injury in rats.

Authors:  Bin Zhang; Eric J West; Ken C Van; Gene G Gurkoff; Jia Zhou; Xiu-Mei Zhang; Alan P Kozikowski; Bruce G Lyeth
Journal:  Brain Res       Date:  2008-06-11       Impact factor: 3.252

7.  Identification of HDAC6-Selective Inhibitors of Low Cancer Cell Cytotoxicity.

Authors:  Irina N Gaisina; Werner Tueckmantel; Andrey Ugolkov; Sida Shen; Jessica Hoffen; Oleksii Dubrovskyi; Andrew Mazar; Renee A Schoon; Daniel Billadeau; Alan P Kozikowski
Journal:  ChemMedChem       Date:  2015-11-23       Impact factor: 3.466

8.  Pharmacokinetics-pharmacodynamics and antitumor activity of mercaptoacetamide-based histone deacetylase inhibitors.

Authors:  Zacharoula Konsoula; Hong Cao; Alfredo Velena; Mira Jung
Journal:  Mol Cancer Ther       Date:  2009-09-29       Impact factor: 6.261

9.  Novel inhibitor of Plasmodium histone deacetylase that cures P. berghei-infected mice.

Authors:  S Agbor-Enoh; C Seudieu; E Davidson; A Dritschilo; M Jung
Journal:  Antimicrob Agents Chemother       Date:  2009-02-17       Impact factor: 5.191

10.  Involvement of P-glycoprotein and multidrug resistance associated protein 1 on the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells.

Authors:  Zacharoula Konsoula; Mira Jung
Journal:  Biol Pharm Bull       Date:  2009-01       Impact factor: 2.233
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