| Literature DB >> 15713390 |
Pauline C Ting1, Joe F Lee, Jie Wu, Shelby P Umland, Robert Aslanian, Jianhua Cao, Youhao Dong, Charles G Garlisi, Eric J Gilbert, Ying Huang, James Jakway, Joseph Kelly, Zhidan Liu, Stuart McCombie, Himanshu Shah, Fang Tian, Yuntao Wan, Neng-Yang Shih.
Abstract
Bipiperidine amide 1 has been identified as a CC chemokine receptor 3 (CCR3) antagonist. Optimization of its structure-activity relationship has resulted in the identification of cis (R,R)-4-[(3,4-dichlorophenyl)methyl]-3-hydroxymethyl-1'(6-quinolinylcarbonyl)-1,4'-bipiperidine 14n, which exhibits potent receptor affinity and inhibition of both calcium flux and eosinophil chemotaxis.Entities:
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Year: 2005 PMID： 15713390 DOI： 10.1016/j.bmcl.2005.01.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823