| Literature DB >> 15713382 |
Jin Hee Ahn1, Jin Ah Kim, Hye-Min Kim, Hyuk-Man Kwon, Sun-Chul Huh, Sang Dal Rhee, Kwang Rok Kim, Sung-Don Yang, Sung-Dae Park, Jae Mok Lee, Sung Soo Kim, Hyae Gyeong Cheon.
Abstract
A new series of pyrazolidine derivatives was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV). Compound 9i was the most active in this series, exhibited IC50 value of 1.56 microM and ED50 value of 80 mg/kg (in vivo DP-IV inhibition; po).Entities:
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Year: 2005 PMID： 15713382 DOI： 10.1016/j.bmcl.2005.01.020
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823