| Literature DB >> 15713378 |
Roberto D'Alessio1, Alberto Bargiotti, Suzanne Metz, M Gabriella Brasca, Alexander Cameron, Antonella Ermoli, Aurelio Marsiglio, Paolo Polucci, Fulvia Roletto, Marcellino Tibolla, Michael L Vazquez, Anna Vulpetti, Paolo Pevarello.
Abstract
The synthesis and the preliminary expansion of this new class of CDK2 inhibitors are presented. The synthesis was accomplished using a solution-phase protocol amenable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. Following a medicinal chemistry program aimed at improving cell permeability and selectivity, a series of compounds with nanomolar activity in the biochemical assay and able to efficiently inhibit tumor cell proliferation has been obtained.Entities:
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Year: 2005 PMID： 15713378 DOI： 10.1016/j.bmcl.2005.01.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823