| Literature DB >> 15713270 |
Melissa Birkett1, Katherine V Fite.
Abstract
Serotonin (5-HT) immunostained sections were analyzed using integrated optical density (IOD) measures obtained throughout the dorsal raphe nucleus (DRN) in Mongolian gerbils at selected times during a 12:12 h light:dark cycle. Substantial diurnal variation occurred in 5-HT neuronal staining density, with lowest and highest IOD values occurring at the light/dark and dark/light transitions, respectively. The injection of pargyline and tryptophan increased 5-HT immunostaining comparable to the highest level observed in control animals. Transitions between light and dark periods appear to be major environmental events that influence 5-HT levels in the DRN.Entities:
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Year: 2005 PMID： 15713270 DOI： 10.1016/j.brainres.2004.11.053
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252