Effects of early immobilization on the functional capacity of dystrophic (ReJ 129 dy/dy) mouse leg muscles.

Hindleg muscles of dystrophic (ReJ 129 dy/dy) mice were immobilized during the second post-natal week. Two months after remobilization histopathological features and isometric force characteristics of the m. extensor digitorum longus (EDL) and the m. tibialis anterior (TA) were studied. As a result of early transient immobilization significant differences were observed in muscle morphology and isometric force compared with untreated dystrophic muscles. Restriction of dynamic use of the muscles during this second post-natal week largely prevents the muscles of dystrophic mice from becoming affected by the disease process. Even after two months of remobilization pathology appears to be reduced.