Literature DB >> 15712594

Regular consumption of a flavanol-rich chocolate can improve oxidant stress in young soccer players.

Cesar G Fraga1, Lucas Actis-Goretta, Javier I Ottaviani, Fernando Carrasquedo, Silvina B Lotito, Sheryl Lazarus, Harold H Schmitz, Carl L Keen.   

Abstract

The consumption of a diet rich in certain flavonoids, including the flavanol sub-class, has been associated with a reduced risk for vascular disease. We evaluated the effects of the regular consumption (14 d) of a flavanol-containing milk chocolate (FCMC) or cocoa butter chocolate (CBC) on variables related to vascular disease risk, oxidative stress and physical activity. Twenty-eight free-living, young (18-20 years old) male soccer players consumed daily 105 g of FCMC (168 mg of flavanols) or CBC (< 5 mg of flavanols), as part of their normal diet. The consumption of FCMC was significantly associated with a decrease in diastolic blood pressure (- 5 mm Hg), mean blood pressure (- 5 mm Hg), plasma cholesterol (-11%), LDL-cholesterol (-15%), malondialdehyde (- 12%), urate (- 11%) and lactate dehydrogenase (LDH) activity (- 11%), and an increase in vitamin E/cholesterol (+ 12%). No relevant changes in these variables were associated with CBC consumption. No changes in the plasma levels of (-)-epicatechin were observed following analysis of fasting blood samples. In conclusion, FCMC consumption was associated with changes in several variables often associated with cardiovascular health and oxidant stress. The presence of significant quantities of flavanols in FCMC is likely to have been one of the contributing factors to these results.

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Year:  2005        PMID: 15712594      PMCID: PMC2270716          DOI: 10.1080/10446670410001722159

Source DB:  PubMed          Journal:  Clin Dev Immunol        ISSN: 1740-2522


  30 in total

1.  (-)-Epicatechin prevents TNFα-induced activation of signaling cascades involved in inflammation and insulin sensitivity in 3T3-L1 adipocytes.

Authors:  Marcela A Vazquez-Prieto; Ahmed Bettaieb; Fawaz G Haj; César G Fraga; Patricia I Oteiza
Journal:  Arch Biochem Biophys       Date:  2012-03-08       Impact factor: 4.013

2.  Effect of low molecular grape seed proanthocyanidins on blood pressure and lipid homeostasis in cafeteria diet-fed rats.

Authors:  Z Pons; L Guerrero; M Margalef; L Arola; A Arola-Arnal; B Muguerza
Journal:  J Physiol Biochem       Date:  2014-03-09       Impact factor: 4.158

Review 3.  Cocoa Flavanol Supplementation and Exercise: A Systematic Review.

Authors:  Lieselot Decroix; Danusa Dias Soares; Romain Meeusen; Elsa Heyman; Cajsa Tonoli
Journal:  Sports Med       Date:  2018-04       Impact factor: 11.136

Review 4.  Nutritional Supplements for the Treatment of Hypertension: A Practical Guide for Clinicians.

Authors:  Jeffrey M Turner; Erica S Spatz
Journal:  Curr Cardiol Rep       Date:  2016-12       Impact factor: 2.931

Review 5.  Effect of dark chocolate on arterial function in healthy individuals: cocoa instead of ambrosia?

Authors:  Charalambos Vlachopoulos; Nikolaos Alexopoulos; Christodoulos Stefanadis
Journal:  Curr Hypertens Rep       Date:  2006-06       Impact factor: 5.369

Review 6.  Dark chocolate: consumption for pleasure or therapy?

Authors:  Giuseppe Lippi; Massimo Franchini; Martina Montagnana; Emmanuel J Favaloro; Gian Cesare Guidi; Giovanni Targher
Journal:  J Thromb Thrombolysis       Date:  2008-09-23       Impact factor: 2.300

7.  Does chocolate reduce blood pressure? A meta-analysis.

Authors:  Karin Ried; Thomas Sullivan; Peter Fakler; Oliver R Frank; Nigel P Stocks
Journal:  BMC Med       Date:  2010-06-28       Impact factor: 8.775

Review 8.  Cocoa, chocolate, and cardiovascular disease.

Authors:  Monica Galleano; Patricia I Oteiza; Cesar G Fraga
Journal:  J Cardiovasc Pharmacol       Date:  2009-12       Impact factor: 3.105

9.  (-)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress.

Authors:  Ahmed Bettaieb; Marcela A Vazquez Prieto; Cecilia Rodriguez Lanzi; Roberto M Miatello; Fawaz G Haj; César G Fraga; Patricia I Oteiza
Journal:  Free Radic Biol Med       Date:  2014-04-16       Impact factor: 7.376

10.  Dark chocolate or tomato extract for prehypertension: a randomised controlled trial.

Authors:  Karin Ried; Oliver R Frank; Nigel P Stocks
Journal:  BMC Complement Altern Med       Date:  2009-07-08       Impact factor: 3.659

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