| Literature DB >> 15711769 |
M Eva Alonso1, M Josefa Bello, Dolores Arjona, Pilar Gonzalez-Gomez, Cinthia Amiñoso, Isabel Lopez-Marín, Jose M de Campos, Alberto Isla, Jesús Vaquero, Manuel Gutierrez, Jose L Sarasa, Juan A Rey.
Abstract
Loss of 1p heterozygosity is one of the most characteristic events in oligodendrogliomas. Several genes located in this region have been previously studied to find the target gene implicated in the development of this tumor without success. Patched-2, RIZ1 and KIF1B are novel oncosuppressor genes located at 1p and involved in different kinds of tumors. We have studied these genes and p18(ink4c) using PCR/SSCP methods to detect sequence variations in a series of 40 oligodendrogliomas in which the allelic status at 1p was analyzed. Polymorphisms or no sequence changes were detected in all four genes analyzed. None of the genes analyzed seem to be the target-gene mapped at 1p involved by mutation in oligodendroglioma development.Entities:
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Year: 2005 PMID： 15711769
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906