Literature DB >> 15710871

Cholesterol detoxification by the nuclear pregnane X receptor.

Steven A Kliewer1.   

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Year:  2005        PMID： 15710871      PMCID： PMC549480          DOI： 10.1073/pnas.0500159102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  19 in total

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2.  Humanized xenobiotic response in mice expressing nuclear receptor SXR.

Authors:  W Xie; J L Barwick; M Downes; B Blumberg; C M Simon; M C Nelson; B A Neuschwander-Tetri; E M Brunt; P S Guzelian; R M Evans
Journal:  Nature       Date:  2000-07-27       Impact factor: 49.962

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Authors:  G A Kullak-Ublick; P J Meier
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4.  The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity.

Authors:  J L Staudinger; B Goodwin; S A Jones; D Hawkins-Brown; K I MacKenzie; A LaTour; Y Liu; C D Klaassen; K K Brown; J Reinhard; T M Willson; B H Koller; S A Kliewer
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-13       Impact factor: 11.205

5.  Biliary flow after microsomal enzyme induction.

Authors:  C D Klaassen
Journal:  J Pharmacol Exp Ther       Date:  1969-08       Impact factor: 4.030

6.  Metabolism of 4 beta -hydroxycholesterol in humans.

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7.  Oxidized products of cholesterol: dietary and metabolic origin, and proatherosclerotic effects (review).

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8.  Alteration of the degree of biliary cholesterol saturation in the hamster and rat by manipulation of the pools of preformed and newly synthesized cholesterol.

Authors:  S D Turley; D K Spady; J M Dietschy
Journal:  Gastroenterology       Date:  1983-02       Impact factor: 22.682

9.  CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.

Authors:  Sarita D Shenoy; Thomas A Spencer; Nancy A Mercer-Haines; Masumeh Alipour; Mary D Gargano; Melissa Runge-Morris; Thomas A Kocarek
Journal:  Drug Metab Dispos       Date:  2004-01       Impact factor: 3.922

10.  Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance.

Authors:  Isabelle Dussault; Hye-Dong Yoo; Min Lin; Eric Wang; Ming Fan; Ashok K Batta; Gerald Salen; Sandra K Erickson; Barry M Forman
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2.  The broad anti-viral agent glycyrrhizin directly modulates the fluidity of plasma membrane and HIV-1 envelope.

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3.  Opioid Use and Rate of Nicotine Metabolism Among Pregnant Smokers.

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Review 4.  Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis.

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5.  Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts.

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Review 6.  Gene-activation mechanisms in the regression of atherosclerosis, elimination of diabetes type 2, and prevention of dementia.

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7.  Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.

Authors:  Yipeng Sui; Zhaojie Meng; Jianzhong Chen; Jingwei Liu; Rebecca Hernandez; Miko B Gonzales; Taesik Gwag; Andrew J Morris; Changcheng Zhou
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