Literature DB >> 15710585

Trisomy 11 in myeloid malignancies is associated with internal tandem duplication of both MLL and FLT3 genes.

Giovanna Rege-Cambrin, Emilia Giugliano, Lucienne Michaux, Michel Stul, Patrizia Scaravaglio, Anna Serra, Giuseppe Saglio, Anne Hagemeijer.   

Abstract

In 20 patients with myeloid malignancies and isolated trisomy 11 an internal tandem duplication of the MLL and FLT3 genes was observed in 41% and 31% of the cases, respectively; 80% of the FLT3+ cases showed MLL self-fusion. Concomitant presence of MLL and FLT3 anomalies could be relevant in determining the poor outcome of patients with acute myeloid leukemia with trisomy 11.

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Year:  2005        PMID： 15710585

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  4 in total

1.  Trisomy 11 as an isolated abnormality in acute myeloid leukemia is associated with unfavorable prognosis but not with an NPM1 or KIT mutation.

Authors:  Faisal M Alseraye; Zhuang Zuo; Carlos Bueso-Ramos; Sa Wang; L Jeffrey Medeiros; Gary Lu
Journal:  Int J Clin Exp Pathol       Date:  2011-04-25

Review 2.  Histone deacetylase inhibitors and epigenetic regulation in lymphoid malignancies.

Authors:  Diana Markozashvili; Vincent Ribrag; Yegor S Vassetzky
Journal:  Invest New Drugs       Date:  2015-09-30       Impact factor: 3.850

3.  Gene mutations and molecularly targeted therapies in acute myeloid leukemia.

Authors:  Eleftheria Hatzimichael; Georgios Georgiou; Leonidas Benetatos; Evangelos Briasoulis
Journal:  Am J Blood Res       Date:  2013-01-17

4.  Cancer epigenetics: new therapies and new challenges.

Authors:  Eleftheria Hatzimichael; Tim Crook
Journal:  J Drug Deliv       Date:  2013-02-26
  4 in total

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