| Literature DB >> 15710470 |
M van der Flier1, F E Coenjaerts, P N Mwinzi, E Rijkers, M Ruyken, J Scharringa, J L L Kimpen, A I M Hoepelman, S P M Geelen.
Abstract
To determine the contribution of vascular endothelial growth factor (VEGF) to cerebral edema formation in bacterial meningitis, we used a VEGF neutralizing antibody to block VEGF in rabbits, following induction of meningitis by intracisternal inoculation with 10(9) heat-killed pneumococci. At 8 h, cerebrospinal fluid (CSF) VEGF was significantly elevated in infected untreated animals, and correlated with CSF white blood cell (WBC) count (r=0.56, P=0.004), and brain water content (r=0.42, P=0.04). Blocking of VEGF did not attenuate brain edema, blood-brain barrier disruption, or CSF pleocytosis. The functional role of VEGF in the pathophysiology of BM remains elusive.Entities:
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Year: 2005 PMID： 15710470 DOI： 10.1016/j.jneuroim.2004.11.013
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478