Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Relationship between alpha 7 nAChR and apoptosis in human lymphocytes.

Literature DB >> 15710468

Relationship between alpha 7 nAChR and apoptosis in human lymphocytes.

María José De Rosa¹, María Del Carmen Esandi, Andrés Garelli, Diego Rayes, Cecilia Bouzat.

Abstract

The presence of nicotinic receptors (nAChRs) in blood cells has been demonstrated. However, little is known about their functional roles. We have detected mRNA of alpha7 nAChR in peripheral human lymphocytes and determined that its expression is highly variable among individuals and within the same individual at different times. Upregulation of alpha7 is systematically observed after incubation of lymphocytes with nicotine or alpha-bungarotoxin. In addition, the incubation with these drugs decreases the percentage of apoptotic cells induced by the exposure to cortisol. Our results suggest that alpha7 nAChRs are involved in the modulation of cortisol-induced apoptosis.

Entities: Chemical Species

Mesh：

Substances：

Year: 2004 PMID： 15710468 DOI： 10.1016/j.jneuroim.2004.11.010

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

Keyword Cloud
Cited

24 in total

Review 1. Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.

Authors: Mariana Bartos; Jeremías Corradi; Cecilia Bouzat
Journal: Mol Neurobiol Date: 2009-10-28 Impact factor: 5.590

2. Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals.

Authors: Esmerij P van der Zanden; Francisca W Hilbers; Caroline Verseijden; Rene M van den Wijngaard; Mike Skynner; Kevin Lee; Luis Ulloa; Guy E Boeckxstaens; Wouter J de Jonge
Journal: Neuroimmunomodulation Date: 2012-03-21 Impact factor: 2.492

3. Promoter methylation and tissue-specific transcription of the α7 nicotinic receptor gene, CHRNA7.

Authors: Andrew Canastar; Judith Logel; Sharon Graw; Jessica Finlay-Schultz; Christina Osborne; Milda Palionyte; Carla Drebing; Molly Plehaty; Lisa Wilson; Rosemary Eyeson; Sherry Leonard
Journal: J Mol Neurosci Date: 2011-11-04 Impact factor: 3.444

4. Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder.

Authors: Leomar Y Ballester; Coral M Capó-Vélez; Wilfredo F García-Beltrán; Félix M Ramos; Edwin Vázquez-Rosa; Raymond Ríos; José R Mercado; Roberto I Meléndez; José A Lasalde-Dominicci
Journal: J Biol Chem Date: 2011-11-14 Impact factor: 5.157

5. Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors.

Authors: Junwei Hao; Alain R Simard; Gregory H Turner; Jie Wu; Paul Whiteaker; Ronald J Lukas; Fu-Dong Shi
Journal: Exp Neurol Date: 2010-10-13 Impact factor: 5.330

6. Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.

Authors: Valentin Galitovskiy; Jing Qian; Alexander I Chernyavsky; Steve Marchenko; Vivian Gindi; Robert A Edwards; Sergei A Grando
Journal: J Immunol Date: 2011-07-22 Impact factor: 5.422

Relationship between alpha 7 nAChR and apoptosis in human lymphocytes.

Review 1. Structural basis of activation of cys-loop receptors: the extracellular-transmembrane interface as a coupling region.

2. Nicotinic acetylcholine receptor expression and susceptibility to cholinergic immunomodulation in human monocytes of smoking individuals.

3. Promoter methylation and tissue-specific transcription of the α7 nicotinic receptor gene, CHRNA7.

4. Up-regulation of the neuronal nicotinic receptor α7 by HIV glycoprotein 120: potential implications for HIV-associated neurocognitive disorder.

5. Attenuation of CNS inflammatory responses by nicotine involves α7 and non-α7 nicotinic receptors.

6. Cytokine-induced alterations of α7 nicotinic receptor in colonic CD4 T cells mediate dichotomous response to nicotine in murine models of Th1/Th17- versus Th2-mediated colitis.

7. Silencing A7-nAChR levels increases the sensitivity of gastric cancer cells to ixabepilone treatment.

8. Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells.

Review 9. Alpha7 nicotinic acetylcholine receptor: a link between inflammation and neurodegeneration.

Review 10. The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation.