Literature DB >> 15710415

Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity.

Birthe R Johannessen1, Lars K Skov, Jette S Kastrup, Ole Kristensen, Caroline Bolwig, Jørgen N Larsen, Michael Spangfort, Kaare Lund, Michael Gajhede.   

Abstract

The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 A resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes.

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Year:  2005        PMID： 15710415     DOI： 10.1016/j.febslet.2004.11.115

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  17 in total

1.  Crystal structure of soluble MD-1 and its interaction with lipid IVa.

Authors:  Sung-il Yoon; Minsun Hong; Gye Won Han; Ian A Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-01       Impact factor: 11.205

2.  Crystal structure and epitope analysis of house dust mite allergen Der f 21.

Authors:  Sze Lei Pang; Kok Lian Ho; Jitka Waterman; Robert Paul Rambo; Aik-Hong Teh; Indran Mathavan; Gemma Harris; Konstantinos Beis; Yee-How Say; Matta Sri Anusha; Yang Yie Sio; Fook Tim Chew; Chyan Leong Ng
Journal:  Sci Rep       Date:  2019-03-20       Impact factor: 4.379

Review 3.  T and B cell responses to HDM allergens and antigens.

Authors:  Wayne R Thomas; Belinda J Hales
Journal:  Immunol Res       Date:  2007       Impact factor: 2.829

4.  A Drosophila protein family implicated in pheromone perception is related to Tay-Sachs GM2-activator protein.

Authors:  Elena Starostina; Aiguo Xu; Heping Lin; Claudio W Pikielny
Journal:  J Biol Chem       Date:  2008-10-24       Impact factor: 5.157

Review 5.  Allergens and their associated small molecule ligands-their dual role in sensitization.

Authors:  Maksymilian Chruszcz; Fook Tim Chew; Karin Hoffmann-Sommergruber; Barry K Hurlburt; Geoffrey A Mueller; Anna Pomés; Juha Rouvinen; Mayte Villalba; Birgitta M Wöhrl; Heimo Breiteneder
Journal:  Allergy       Date:  2021-05-02       Impact factor: 14.710

6.  Transcriptome profiling of the intoxication response of Tenebrio molitor larvae to Bacillus thuringiensis Cry3Aa protoxin.

Authors:  Brenda Oppert; Scot E Dowd; Pascal Bouffard; Lewyn Li; Ana Conesa; Marcé D Lorenzen; Michelle Toutges; Jeremy Marshall; Diana L Huestis; Jeff Fabrick; Cris Oppert; Juan Luis Jurat-Fuentes
Journal:  PLoS One       Date:  2012-04-25       Impact factor: 3.240

7.  Expression of hypoallergenic Der f 2 derivatives with altered intramolecular disulphide bonds induces the formation of novel ER-derived protein bodies in transgenic rice seeds.

Authors:  Lijun Yang; Sakiko Hirose; Kazuya Suzuki; Takachika Hiroi; Fumio Takaiwa
Journal:  J Exp Bot       Date:  2012-02-29       Impact factor: 6.992

8.  Recombinant house dust mite allergens.

Authors:  Susanne Vrtala; Hans Huber; Wayne R Thomas
Journal:  Methods       Date:  2013-07-31       Impact factor: 3.608

Review 9.  Structure of allergens and structure based epitope predictions.

Authors:  Fabio Dall'antonia; Tea Pavkov-Keller; Klaus Zangger; Walter Keller
Journal:  Methods       Date:  2013-07-23       Impact factor: 3.608

10.  Midgut transcriptome profiling of Anoplophora glabripennis, a lignocellulose degrading cerambycid beetle.

Authors:  Erin D Scully; Kelli Hoover; John E Carlson; Ming Tien; Scott M Geib
Journal:  BMC Genomics       Date:  2013-12-04       Impact factor: 3.969
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