Literature DB >> 15710412

DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.

Marian E Durkin1, Miriam R Avner, Chang-Goo Huh, Bao-Zhu Yuan, Snorri S Thorgeirsson, Nicholas C Popescu.   

Abstract

DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions.

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Year:  2005        PMID： 15710412     DOI： 10.1016/j.febslet.2004.12.090

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  54 in total

1.  Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process.

Authors:  Yi-Ping Shih; Sarah Y Yuan; Su Hao Lo
Journal:  Cancer Lett       Date:  2017-04-10       Impact factor: 8.679

Review 2.  Cell type-specific signaling function of RhoA GTPase: lessons from mouse gene targeting.

Authors:  Xuan Zhou; Yi Zheng
Journal:  J Biol Chem       Date:  2013-11-07       Impact factor: 5.157

3.  Loci controlling lymphocyte production of interferon c after alloantigen stimulation in vitro and their co-localization with genes controlling lymphocyte infiltration of tumors and tumor susceptibility.

Authors:  Marie Lipoldová; Helena Havelková; Jana Badalova; Jarmila Vojtísková; Lei Quan; Magdaléna Krulova; Yahya Sohrabi; Alphons P Stassen; Peter Demant
Journal:  Cancer Immunol Immunother       Date:  2010-02       Impact factor: 6.968

4.  Effect of FAK, DLC-1 gene expression on OVCAR-3 proliferation.

Authors:  Huina Liu; Huirong Shi; Yibin Hao; Guoqiang Zhao; Xiaofeng Yang; Yali Wang; Mei Li; Min Liu
Journal:  Mol Biol Rep       Date:  2012-10-19       Impact factor: 2.316

5.  DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity.

Authors:  Veenu Tripathi; Nicholas C Popescu; Drazen B Zimonjic
Journal:  Mol Cell Biol       Date:  2012-04-02       Impact factor: 4.272

6.  GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition.

Authors:  Francis O Enane; Wai Ho Shuen; Xiaorong Gu; Ebrahem Quteba; Bartlomiej Przychodzen; Hideki Makishima; Juraj Bodo; Joanna Ng; Chit Lai Chee; Rebecca Ba; Lip Seng Koh; Janice Lim; Rachael Cheong; Marissa Teo; Zhenbo Hu; Kwok Peng Ng; Jaroslaw Maciejewski; Tomas Radivoyevitch; Alexander Chung; London Lucien Ooi; Yu Meng Tan; Peng-Chung Cheow; Pierce Chow; Chung Yip Chan; Kiat Hon Lim; Lisa Yerian; Eric Hsi; Han Chong Toh; Yogen Saunthararajah
Journal:  J Clin Invest       Date:  2017-07-31       Impact factor: 14.808

7.  Effects of DLC1 Deficiency on Endothelial Cell Contact Growth Inhibition and Angiosarcoma Progression.

Authors:  David Sánchez-Martín; Atsushi Otsuka; Kenji Kabashima; Taekyu Ha; Dunrui Wang; Xiaolan Qian; Douglas R Lowy; Giovanna Tosato
Journal:  J Natl Cancer Inst       Date:  2018-04-01       Impact factor: 13.506

8.  Deleted in liver cancer 2 (DLC2) was dispensable for development and its deficiency did not aggravate hepatocarcinogenesis.

Authors:  Tai On Yau; Thomas Ho Yin Leung; Sandra Lam; Oi Fung Cheung; Edmund Kwok Kwan Tung; Pek Lan Khong; Amy Lam; Sookja Chung; Irene Oi Lin Ng
Journal:  PLoS One       Date:  2009-08-10       Impact factor: 3.240

9.  DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.

Authors:  Y Lin; N-T Chen; Y-P Shih; Y-C Liao; L Xue; S H Lo
Journal:  Oncogene       Date:  2010-03-08       Impact factor: 9.867

10.  Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform.

Authors:  Mohammad G Sabbir; Nichola Wigle; Shauna Loewen; Yuan Gu; Cordula Buse; Geoffrey G Hicks; Michael R A Mowat
Journal:  BMC Biol       Date:  2010-03-03       Impact factor: 7.431
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