| Literature DB >> 15710388 |
Akihiko Nishikimi1, Nahum Meller, Natsuko Uekawa, Ken-ichi Isobe, Martin A Schwartz, Mitsuo Maruyama.
Abstract
A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily includes three genes of which only zizimin1 has been cloned. We report here the cloning of zizimin2, identified in a screen for genes enriched in germinal center B cells. Zizimin2 and zizimin1 have similar primary structures and both proteins bound and activated Cdc42 but not the Cdc42-related proteins TC10 or TCL. Their tissue distributions are distinct, however, with zizimin2 expressed predominantly in lymphocytes and an opposite pattern for zizimin1. Zizimin3 was also analyzed and showed distinct GTPase specificity and tissue distribution.Entities:
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Year: 2005 PMID： 15710388 DOI： 10.1016/j.febslet.2005.01.006
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124