Differential gene expression in WKY and SHR brain following acute and chronic air-puff stress.

This study determined the expression levels of tyrosine hydroxylase (TH), arginine vasopressin (AVP), and prepro-neuropeptide Y (NPY) mRNA in the brain following acute and chronic air-puff stress. Acute stress increased TH gene expression in the locus coeruleus of Wistar-Kyoto (WKY) rats (+80%), but only modestly in spontaneously hypertensive rats (SHR; +19%). Hypothalamic AVP mRNA in SHR was persistently elevated in the supraoptic nucleus (+24% acute; +19% chronic), but reduced in the magnocellular region of the paraventricular nucleus (-15% acute; -20% chronic). In the arcuate nucleus, NPY mRNA expression increased by 60% and 81% in response to acute and chronic air-puff stress, respectively, in SHR. These data suggest differential adaptation to air-puff stress between WKY and SHR.