Literature DB >> 15708536

The case for open-source software in drug discovery.

Warren L DeLano1.   

Abstract

Widespread adoption of open-source software for network infrastructure, web servers, code development, and operating systems leads one to ask how far it can go. Will "open source" spread broadly, or will it be restricted to niches frequented by hopeful hobbyists and midnight hackers? Here we identify reasons for the success of open-source software and predict how consumers in drug discovery will benefit from new open-source products that address their needs with increased flexibility and in ways complementary to proprietary options.

Mesh:

Year:  2005        PMID: 15708536     DOI: 10.1016/S1359-6446(04)03363-X

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  58 in total

1.  Structure and dynamics of the membrane-bound form of Pf1 coat protein: implications of structural rearrangement for virus assembly.

Authors:  Sang Ho Park; Francesca M Marassi; David Black; Stanley J Opella
Journal:  Biophys J       Date:  2010-09-08       Impact factor: 4.033

2.  A canonical cation-π interaction stabilizes the agonist conformation of estrogen-like nuclear receptors.

Authors:  Núria Queralt-Rosinach; Jordi Mestres
Journal:  Eur Biophys J       Date:  2010-04-03       Impact factor: 1.733

3.  A Survey of DICOM Viewer Software to Integrate Clinical Research and Medical Imaging.

Authors:  Daniel Haak; Charles-E Page; Thomas M Deserno
Journal:  J Digit Imaging       Date:  2016-04       Impact factor: 4.056

4.  Molecular dynamics simulations on the oligomer-formation process of the GNNQQNY peptide from yeast prion protein Sup35.

Authors:  Zhuqing Zhang; Hao Chen; Hongjun Bai; Luhua Lai
Journal:  Biophys J       Date:  2007-05-04       Impact factor: 4.033

5.  Anaerobic oxidation of long-chain n-alkanes by the hyperthermophilic sulfate-reducing archaeon, Archaeoglobus fulgidus.

Authors:  Nadia Khelifi; Oulfat Amin Ali; Philippe Roche; Vincent Grossi; Céline Brochier-Armanet; Odile Valette; Bernard Ollivier; Alain Dolla; Agnès Hirschler-Réa
Journal:  ISME J       Date:  2014-04-24       Impact factor: 10.302

6.  Change in structure and ligand binding properties of hyperstable cytochrome c555 from Aquifex aeolicus by domain swapping.

Authors:  Masaru Yamanaka; Satoshi Nagao; Hirofumi Komori; Yoshiki Higuchi; Shun Hirota
Journal:  Protein Sci       Date:  2015-01-14       Impact factor: 6.725

7.  Formation and carbon monoxide-dependent dissociation of Allochromatium vinosum cytochrome c' oligomers using domain-swapped dimers.

Authors:  Masaru Yamanaka; Makoto Hoshizumi; Satoshi Nagao; Ryoko Nakayama; Naoki Shibata; Yoshiki Higuchi; Shun Hirota
Journal:  Protein Sci       Date:  2017-02-14       Impact factor: 6.725

8.  Active-site differences between substrate-free and ritonavir-bound cytochrome P450 (CYP) 3A5 reveal plasticity differences between CYP3A5 and CYP3A4.

Authors:  Mei-Hui Hsu; Eric F Johnson
Journal:  J Biol Chem       Date:  2019-03-29       Impact factor: 5.157

9.  14-3-3:Shc scaffolds integrate phosphoserine and phosphotyrosine signaling to regulate phosphatidylinositol 3-kinase activation and cell survival.

Authors:  Emma F Barry; Fernando A Felquer; Jason A Powell; Lisa Biggs; Frank C Stomski; Andrea Urbani; Hayley Ramshaw; Peter Hoffmann; Matthew C Wilce; Michele A Grimbaldeston; Angel F Lopez; Mark A Guthridge
Journal:  J Biol Chem       Date:  2009-02-13       Impact factor: 5.157

10.  The structure of HLA-DR52c: comparison to other HLA-DRB3 alleles.

Authors:  Shaodong Dai; Frances Crawford; Philippa Marrack; John W Kappler
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-12       Impact factor: 11.205

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