Ming Jin1, Jin-rong Li, Wei Wu. 1. Department of Pharmacology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China. jinzang@public3.bta.net.cn
Abstract
OBJECTIVE: To observe the antioxidative effect of Safflor Yellow (SY). METHOD: Hydroxyl radical scavenge effect of SY was tested with 1,10-phenanthroline-Fe2+ oxidative assay. Lipid peroxidation of mouse liver suspension was measured with thiobarbituric acid colorimetry technique. Hemocytocatheresis was determined with colorimetry. RESULT: Hydroxyl radical could be scavenged by 1.39 to 3.42 g x L(-1) SY dose dependently. Mouse liver suspension peroxidation was inhibited by 77.8 to 776.1 mg x L(-1) SY dosage dependently. Hemocytocatheresis was attenuated by 37.1 to 297.1 mg x L(-1) SY dose dependently. CONCLUSION: SY is an antioxidative part of Carthamus tinctorius.
OBJECTIVE: To observe the antioxidative effect of Safflor Yellow (SY). METHOD:Hydroxyl radical scavenge effect of SY was tested with 1,10-phenanthroline-Fe2+ oxidative assay. Lipid peroxidation of mouse liver suspension was measured with thiobarbituric acid colorimetry technique. Hemocytocatheresis was determined with colorimetry. RESULT: Hydroxyl radical could be scavenged by 1.39 to 3.42 g x L(-1) SY dose dependently. Mouse liver suspension peroxidation was inhibited by 77.8 to 776.1 mg x L(-1) SY dosage dependently. Hemocytocatheresis was attenuated by 37.1 to 297.1 mg x L(-1) SY dose dependently. CONCLUSION: SY is an antioxidative part of Carthamus tinctorius.