OBJECTIVE: To study the effect of Spatholobus suberectus on proliferation and the hematonic mechanism. METHOD: The techniques of culture of hematopoietic cell and hematopoietic growth factor (HGF) assay were used. RESULT: Spatholobus suberectus could obviously promote the proliferation of bone marrow cells in healthy and anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with S. suberectus had much stronger stimulating effects on hematopoietic cells. CONCLUSION: S. suberectus may enhance hematopoiesis by directly or indirectly stimulating stroma cell in hematopoietic inductive microenvironment and muscle tissue to secrete some HGF (Epo, GM-CSF, IL, and MK-CSF). This is one of the biological mechanisms for hematonic effect of S. suberectus.
OBJECTIVE: To study the effect of Spatholobus suberectus on proliferation and the hematonic mechanism. METHOD: The techniques of culture of hematopoietic cell and hematopoietic growth factor (HGF) assay were used. RESULT: Spatholobus suberectus could obviously promote the proliferation of bone marrow cells in healthy and anaemic mice. The culture media of spleen cell, macrophage, lung and skeletal muscle treated with S. suberectus had much stronger stimulating effects on hematopoietic cells. CONCLUSION:S. suberectus may enhance hematopoiesis by directly or indirectly stimulating stroma cell in hematopoietic inductive microenvironment and muscle tissue to secrete some HGF (Epo, GM-CSF, IL, and MK-CSF). This is one of the biological mechanisms for hematonic effect of S. suberectus.