Literature DB >> 15705423

Interleukin-2, interleukin-15, and their roles in human natural killer cells.

Brian Becknell1, Michael A Caligiuri.   

Abstract

Natural killer (NK) cells are CD56+CD3- large granular lymphocytes that constitute a key component of the human innate immune response. In addition to their potent cytolytic activity, NK cells elaborate a host of immunoregulatory cytokines and chemokines that play a crucial role in pathogen clearance. Furthermore, interactions between NK and other immune cells are implicated in triggering the adaptive, or antigen-specific, immune response. Interleukin-2 (IL-2) and IL-15 are two distinct cytokines with partially overlapping properties that are implicated in the development, homeostasis, and function of NK cells. This review examines the pervasive effects of IL-2 and IL-15 on NK cell biology, with an emphasis on recent discoveries and lingering challenges in the field.

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Year:  2005        PMID： 15705423     DOI： 10.1016/S0065-2776(04)86006-1

Source DB:  PubMed          Journal:  Adv Immunol        ISSN： 0065-2776            Impact factor:   3.543


  98 in total

1.  Natural killer cell engineering for cellular therapy of cancer.

Authors:  D R Shook; D Campana
Journal:  Tissue Antigens       Date:  2011-12

Review 2.  Generation of natural killer cells from hematopoietic stem cells in vitro for immunotherapy.

Authors:  Martha Luevano; Alejandro Madrigal; Aurore Saudemont
Journal:  Cell Mol Immunol       Date:  2012-06-18       Impact factor: 11.530

Review 3.  The Immunologic Mechanisms of Eosinophilic Esophagitis.

Authors:  David A Hill; Jonathan M Spergel
Journal:  Curr Allergy Asthma Rep       Date:  2016-02       Impact factor: 4.806

4.  Bench-to-bedside translation of interleukin-15 for immunotherapy: principles and challenges.

Authors:  Chalet Tan; Thomas A Waldmann
Journal:  Expert Opin Drug Deliv       Date:  2020-05-19       Impact factor: 6.648

5.  Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite.

Authors:  Crescent L Combe; Magali M Moretto; Joseph D Schwartzman; Jason P Gigley; David J Bzik; Imtiaz A Khan
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-13       Impact factor: 11.205

6.  Identification of human STAT5-dependent gene regulatory elements based on interspecies homology.

Authors:  Erik A Nelson; Sarah R Walker; Wei Li; X Shirley Liu; David A Frank
Journal:  J Biol Chem       Date:  2006-07-13       Impact factor: 5.157

7.  Selective dependence of H2-M3-restricted CD8 responses on IL-15.

Authors:  Jürgen R Müller; Thomas A Waldmann; Sigrid Dubois
Journal:  J Immunol       Date:  2012-02-06       Impact factor: 5.422

8.  Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC.

Authors:  Isabel Barao; Maite Alvarez; Erik Ames; Mark T Orr; Heather E Stefanski; Bruce R Blazar; Lewis L Lanier; Stephen K Anderson; Doug Redelman; William J Murphy
Journal:  Blood       Date:  2011-04-15       Impact factor: 22.113

Review 9.  Strategies to enhance NK cell function for the treatment of tumors and infections.

Authors:  Jacquelyn Freund-Brown; Leilani Chirino; Taku Kambayashi
Journal:  Crit Rev Immunol       Date:  2018       Impact factor: 2.214

Review 10.  Exploring the Pathogenic Role and Therapeutic Implications of Interleukin 2 in Autoimmune Hepatitis.

Authors:  Albert J Czaja
Journal:  Dig Dis Sci       Date:  2020-08-24       Impact factor: 3.199
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