Recurrent arthritis in Reiter's syndrome: a function of inapparent chlamydial infection of the synovium?

Present or prior infection with any of several common bacterial pathogens has been strongly implicated in the development of Reiter's syndrome (RS). However, because Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen in the western hemisphere, this organism has emerged as a major causative agent of the disease. An important but as yet poorly understood aspect of chlamydia-related RS is the recurrence of active arthritis in the absence of any overt infection or reinfection with the organism. In this article, a large body of published clinical and experimental observations strongly suggesting that some chlamydial infections in humans can be inapparent--not detectable by standard culture or antibody-based laboratory screening methods--is reviewed. The authors' own initial molecular genetic studies, which support that contention, are summarized. Based on these data, the argument is developed that not only does inapparent chlamydial infection occur in humans, but such infections may have significant consequences in terms of the pathogenesis of RS, including the possible causation of recurrent episodes of disease in the absence of active infection. The therapeutic implications of potential inapparent chlamydial infections as they relate to RS are discussed.