| Literature DB >> 15704914 |
Mikkel F Jacobsen1, John E Moses, Robert M Adlington, Jack E Baldwin.
Abstract
The total synthesis of the nitrophenyl pyrones, (+/-)-aureothin and (+/-)-N-acetylaureothamine, starting from known 2-ethyl-6-methoxy-3,5-dimethyl-4H-pyran-4-one are described. The key steps involved in the synthesis are the construction of the tetrahydrofuran motif using a palladium-catalyzed cycloaddition and the ruthenium-catalyzed cross-metathesis reaction of an alkenyl boronic ester. [reaction: see text]Entities:
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Year: 2005 PMID： 15704914 DOI： 10.1021/ol047594l
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005