Yong Liu1, Ying Cen, Tang Ying, Xuewen Xu. 1. Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu Sichuan 610041, P R China.
Abstract
OBJECTIVE: To study the effect of myofibroblast on the development of pathological scar. METHODS: From 1998 to 2000, 14 cases of keloid(k), 13 cases of hypertrophic scar(HS), and 7 cases of scar were studied through immunohistochemistry and electron microscope. RESULTS: Myofibroblasts were often observed in the hypertrophic HS by electron microscope, but no myofibroblast was observed in the K and NS. alpha-SM-actin was expressed in fibroblast of HS, but was not expressed in K and NS. CONCLUSION: Myofibroblast may play a role in the development of hypertrophic scar. The difference between the absence of myofibroblast in keloid and the invasion of keloid deserves further study.
OBJECTIVE: To study the effect of myofibroblast on the development of pathological scar. METHODS: From 1998 to 2000, 14 cases of keloid(k), 13 cases of hypertrophic scar(HS), and 7 cases of scar were studied through immunohistochemistry and electron microscope. RESULTS: Myofibroblasts were often observed in the hypertrophic HS by electron microscope, but no myofibroblast was observed in the K and NS. alpha-SM-actin was expressed in fibroblast of HS, but was not expressed in K and NS. CONCLUSION: Myofibroblast may play a role in the development of hypertrophic scar. The difference between the absence of myofibroblast in keloid and the invasion of keloid deserves further study.