[Tumor necrosis factor alfa (TNFalpha) and insulin resistance].

Obesity and diabetes mellitus type 2 belong among the most frequent illnesses and are categorized among the dominant risk factors for cardiovascular disease in all developed countries. There is a causal relation between insulin resistance and the origin of these risk factors of the cardiovascular morbidity and mortality. Numerous studies have attemted to identify the mechanisms linking obesity with insulin resistance and type 2 diabetes. Numbers of factors have been suggested as having a role in pathogenesis of obesity-related insulin resistance. One of these factors is tumor necrosis factor alfa (TNFalpha).