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Literature DB >> 15703270

Renin inhibition: what are the therapeutic opportunities?

Abstract

Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has become a crucial element in cardiovascular and renal medicine. This review evaluates the potential of renin inhibition as an adjunct to therapies that depend on renin system interruption.

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Year: 2005 PMID： 15703270 DOI： 10.1681/ASN.2004100874

Source DB: PubMed Journal: J Am Soc Nephrol ISSN： 1046-6673 Impact factor: 10.121

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Cited

32 in total

1. Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.

Authors: L Gabriel Navar
Journal: J Appl Physiol (1985) Date: 2010-12

2. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects.

Authors: Sujata Vaidyanathan; Joanne Jermany; Chingming Yeh; Marie-Noelle Bizot; Riccardo Camisasca
Journal: Br J Clin Pharmacol Date: 2006-12 Impact factor: 4.335

Review 3. Aliskiren: the first direct renin inhibitor for hypertension.

Authors: Anton H van den Meiracker; A H Jan Danser
Journal: Curr Cardiol Rep Date: 2007-11 Impact factor: 2.931

4. Aliskiren as an antiproteinuric add-on therapy in primary membranous nephropathy.

Authors: Ankur Gupta; Ambar Khaira; Bakshish Singh; Dipankar M Bhowmik; Suresh C Tiwari
Journal: Clin Exp Nephrol Date: 2009-03-03 Impact factor: 2.801

Review 5. Sequence, Structural Analysis and Metrics to Define the Unique Dynamic Features of the Flap Regions Among Aspartic Proteases.

Authors: Lara McGillewie; Muthusamy Ramesh; Mahmoud E Soliman
Journal: Protein J Date: 2017-10 Impact factor: 2.371

Review 6. Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control.

Authors: Carlos M Ferrario
Journal: Life Sci Date: 2009-12-01 Impact factor: 5.037

Renin inhibition: what are the therapeutic opportunities?

1. Counterpoint: Activation of the intrarenal renin-angiotensin system is the dominant contributor to systemic hypertension.

2. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects.

Review 3. Aliskiren: the first direct renin inhibitor for hypertension.

4. Aliskiren as an antiproteinuric add-on therapy in primary membranous nephropathy.

Review 5. Sequence, Structural Analysis and Metrics to Define the Unique Dynamic Features of the Flap Regions Among Aspartic Proteases.

Review 6. Addressing the theoretical and clinical advantages of combination therapy with inhibitors of the renin-angiotensin-aldosterone system: antihypertensive effects and benefits beyond BP control.

7. Re-examining RAS-blocking treatment regimens for abrogating progression of chronic kidney disease.

8. Renin dynamics in adipose tissue: adipose tissue control of local renin concentrations.

9. Intratubular Renin-Angiotensin System in Hypertension.

Review 10. Direct renin inhibition: clinical pharmacology.