STUDY OBJECTIVE: To evaluate the feasibility of fluorescence diagnosis of nonpigmented (red and white) endometriotic lesions with 20 mg/kg of 5-aminolevulinc acid (5-ALA) 5-7 and 10-14 hours before surgery. DESIGN: Prospective analysis (Canadian Task Force classification II-2). SETTING: University hospital. PATIENTS: Twenty-four consecutive patients with suspected endometriosis undergoing laparoscopy. INTERVENTION: Laparoscopic surgery under white light illumination and fluorescence diagnosis. MEASUREMENTS AND MAIN RESULTS: The total number of endometriotic lesions detected under white light illumination was compared with the number of lesions detected with fluorescence diagnosis. Fluorescence diagnosis yielded an overall improvement of 35% in the detection of nonpigmented endometriotic lesions compared with white light illumination. Sensitivity (91%) and specificity (79%) were similar 5-7 and 10-14 hours before surgery. CONCLUSION: The dosage of 20 mg/kg body weight of 5-ALA is feasible for fluorescence diagnosis of nonpigmented endometriosis. Sensitivity of fluorescence diagnosis with 20 mg/kg is similar to that achieved with a 30-mg/kg dose. Sensitivity does not change within the application period 5-7 and 10-14 hours before surgery.
STUDY OBJECTIVE: To evaluate the feasibility of fluorescence diagnosis of nonpigmented (red and white) endometriotic lesions with 20 mg/kg of 5-aminolevulinc acid (5-ALA) 5-7 and 10-14 hours before surgery. DESIGN: Prospective analysis (Canadian Task Force classification II-2). SETTING: University hospital. PATIENTS: Twenty-four consecutive patients with suspected endometriosis undergoing laparoscopy. INTERVENTION: Laparoscopic surgery under white light illumination and fluorescence diagnosis. MEASUREMENTS AND MAIN RESULTS: The total number of endometriotic lesions detected under white light illumination was compared with the number of lesions detected with fluorescence diagnosis. Fluorescence diagnosis yielded an overall improvement of 35% in the detection of nonpigmented endometriotic lesions compared with white light illumination. Sensitivity (91%) and specificity (79%) were similar 5-7 and 10-14 hours before surgery. CONCLUSION: The dosage of 20 mg/kg body weight of 5-ALA is feasible for fluorescence diagnosis of nonpigmented endometriosis. Sensitivity of fluorescence diagnosis with 20 mg/kg is similar to that achieved with a 30-mg/kg dose. Sensitivity does not change within the application period 5-7 and 10-14 hours before surgery.
Authors: Abraham S Moses; Ananiya A Demessie; Olena Taratula; Tetiana Korzun; Ov D Slayden; Oleh Taratula Journal: Small Date: 2021-01-25 Impact factor: 13.281
Authors: Marit C I Lier; Stijn L Vlek; Marjolein Ankersmit; Peter M van de Ven; Judith J M L Dekker; Maaike C G Bleeker; Velja Mijatovic; Jurriaan B Tuynman Journal: Surg Endosc Date: 2019-04-26 Impact factor: 4.584