| Literature DB >> 15698769 |
Uwe Albrecht1, Michael Lalk, Peter Langer.
Abstract
A series of novel 2-vinylchroman-4-ones, analogues of the natural products Aposphaerin A and B, were identified as potent antibiotics. Derivatives exhibit a significant activity against multiresistant strains of S. aureus, such as MRSA (methicillin resistant S. aureus). The 2-vinylchroman-4-ones were efficiently prepared by Lewis acid mediated conjugate addition of vinylmagnesium bromide to chromones.Entities:
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Year: 2005 PMID： 15698769 DOI： 10.1016/j.bmc.2004.12.031
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641