Literature DB >> 15697625

Optimal path to epigenetic switching.

David Marin Roma1, Ruadhan A O'Flanagan, Andrei E Ruckenstein, Anirvan M Sengupta, Ranjan Mukhopadhyay.   

Abstract

We use large deviation methods to calculate rates of noise-induced transitions between states in multistable genetic networks. We analyze a synthetic biochemical circuit, the toggle switch, and compare the results to those obtained from a numerical solution of the master equation.

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Year:  2005        PMID： 15697625     DOI： 10.1103/PhysRevE.71.011902

Source DB:  PubMed          Journal:  Phys Rev E Stat Nonlin Soft Matter Phys        ISSN： 1539-3755


  22 in total

1.  The potential landscape of genetic circuits imposes the arrow of time in stem cell differentiation.

Authors:  Jin Wang; Li Xu; Erkang Wang; Sui Huang
Journal:  Biophys J       Date:  2010-07-07       Impact factor: 4.033

2.  DNA-Binding Kinetics Determines the Mechanism of Noise-Induced Switching in Gene Networks.

Authors:  Margaret J Tse; Brian K Chu; Mahua Roy; Elizabeth L Read
Journal:  Biophys J       Date:  2015-10-20       Impact factor: 4.033

3.  Epigenetic chromatin silencing: bistability and front propagation.

Authors:  Mohammad Sedighi; Anirvan M Sengupta
Journal:  Phys Biol       Date:  2007-11-07       Impact factor: 2.583

4.  DNA looping provides stability and robustness to the bacteriophage lambda switch.

Authors:  Marco J Morelli; Pieter Rein Ten Wolde; Rosalind J Allen
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-01       Impact factor: 11.205

5.  Efficient stochastic simulation of chemical kinetics networks using a weighted ensemble of trajectories.

Authors:  Rory M Donovan; Andrew J Sedgewick; James R Faeder; Daniel M Zuckerman
Journal:  J Chem Phys       Date:  2013-09-21       Impact factor: 3.488

6.  Exponential sensitivity of noise-driven switching in genetic networks.

Authors:  Pankaj Mehta; Ranjan Mukhopadhyay; Ned S Wingreen
Journal:  Phys Biol       Date:  2008-06-16       Impact factor: 2.583

7.  Quantifying the Waddington landscape and biological paths for development and differentiation.

Authors:  Jin Wang; Kun Zhang; Li Xu; Erkang Wang
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-02       Impact factor: 11.205

8.  Effects of molecular noise on bistable protein distributions in rod-shaped bacteria.

Authors:  L Wettmann; M Bonny; K Kruse
Journal:  Interface Focus       Date:  2014-12-06       Impact factor: 3.906

9.  Cellular reprogramming dynamics follow a simple 1D reaction coordinate.

Authors:  Sai Teja Pusuluri; Alex H Lang; Pankaj Mehta; Horacio E Castillo
Journal:  Phys Biol       Date:  2017-12-06       Impact factor: 2.583

10.  Cancer as robust intrinsic state of endogenous molecular-cellular network shaped by evolution.

Authors:  Ping Ao; David Galas; Leroy Hood; Xiaomei Zhu
Journal:  Med Hypotheses       Date:  2007-09-04       Impact factor: 1.538
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