Dyserythropoiesis in 105 patients with visceral leishmaniasis.

Hematologists in the developing world are increasingly involved in diagnosing parasitic diseases that involve the bone marrow. With a worldwide annual incidence of half a million cases and 12 million infected people, visceral leishmaniasis is one such serious disease. It mainly affects malnourishedand economically underprivileged children. Recently, this disease has been seen in acquired immunodeficiency syndrome patients and in travelers to endemic areas. Over an 18-year period, 442 marrow examination requests were received by our department, and 105 cases of visceral leishmaniasis were diagnosed from findings of Leishman-Donovan bodies. Prominent nuclear dyserythropoiesis was shown in 17 patients, 14 of whom had the frank type that is uniquely seen in congenital dyserythropoietic anemia type II. Most of these cases showed an extremely low degree of marrow parasitemia. This degree of nuclear dyserythropoiesis was not found in the majority of the marrows in which parasites were more easily detected. There is a direct and negative correlationbetween frank nuclear dyserythropoiesis and marrow parasitemia. Extended microscopical examination is recommended for the detection of Leishman-Donovan bodies in cases of suspected visceral leishmaniasis when frank dyserythropoiesis is a prominent feature. It is possible that both frank nuclear dyserythropoiesis and marrow parasitemia are etiologically under the influence of a common chemokine or cytokine.