| Literature DB >> 15695167 |
Masahiro Banno1, Tetsuya Mizuno, Hideki Kato, Guiqin Zhang, Jun Kawanokuchi, Jinyan Wang, Reiko Kuno, Shijie Jin, Hideyuki Takeuchi, Akio Suzumura.
Abstract
The free radical scavenger edaravone has been used as an anti-oxidative agent in acute ischemic brain disorders. We examined the effect of edaravone on the production of nitric oxide (NO), reactive oxygen species (ROS) and proinflammatory cytokines by activated microglia, and we also examined its neuroprotective role in cortical neuronal cultures oxidatively stressed by the peroxynitrite donor N-morpholinosydnonimine (SIN-1) or activated microglia. Edaravone significantly suppressed the production of NO and ROS by activated microglia, though it did not suppress production of inflammatory cytokines. In addition, edaravone significantly suppressed neuronal cell death and dendrotoxicity induced by either SIN-1 or activated microglia in a dose-dependent manner. These results suggest that edaravone may function as a neuroprotective agent counteracting oxidative neurotoxicity arising from activated microglia, as occurs in either inflammatory or neurodegenerative disorders of the central nervous system.Entities:
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Year: 2004 PMID： 15695167 DOI： 10.1016/j.neuropharm.2004.10.002
Source DB: PubMed Journal: Neuropharmacology ISSN： 0028-3908 Impact factor: 5.250