Literature DB >> 15694824

Hypercalcemia and pancreatic endocrine neoplasia with elevated PTH-rP: report of two new cases and subject review.

Susanna L Matsen1, Charles J Yeo, Ralph H Hruban, Michael A Choti.   

Abstract

Humoral hypercalcemia of malignancy is widely associated with tumor production of parathyroid hormone related protein (PTH-rP). This peptide functions in endocrine, autocrine and paracrine mechanisms in a manner similar to PTH; increasing renal uptake of calcium, decreasing retention of phosphorous, and stimulating adenylate cyclase and phospholipase C. Although PTH-rP production has been well documented in neoplasms of the exocrine pancreas, we present here two cases of endocrine pancreatic neoplasms elaborating PTH-rP. We then review the literature of previous cases and delve into the pathophysiology of this peptide.

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Year:  2005        PMID： 15694824     DOI： 10.1016/j.gassur.2004.06.012

Source DB:  PubMed          Journal:  J Gastrointest Surg        ISSN： 1091-255X            Impact factor:   3.452


  28 in total

1.  Parathyroid hormone-related protein: a polyhormonal enigma.

Authors:  W A Ratcliffe
Journal:  Equine Vet J       Date:  1997-05       Impact factor: 2.888

Review 2.  Pancreatic cancer and hypercalcemia associated with von Recklinghausen's disease.

Authors:  M Yamamoto; S Nakano; M Mugikura; I Tachibana; Y Ogami; M Otsuki
Journal:  J Gastroenterol       Date:  1996-10       Impact factor: 7.527

3.  Pancreatic islet-cell neoplasia, with secretion of a parathormone-like substance and hypercalcemia.

Authors:  D B Vair; S F Boudreau; E L Reid
Journal:  Can J Surg       Date:  1987-03       Impact factor: 2.089

4.  Enhancement of cyclic adenosine monophosphate content in bone cells by the factor extracted from a pancreatic cancer associated with hypercalcemia.

Authors:  N Nagata; N Kugai; M Maemura; T Akatsu; T Shimauchi; T Kinoshita; H Kosano; O Takatani; H Tsuda; Y Fuse
Journal:  Metabolism       Date:  1986-06       Impact factor: 8.694

5.  PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth.

Authors:  B Lanske; A C Karaplis; K Lee; A Luz; A Vortkamp; A Pirro; M Karperien; L H Defize; C Ho; R C Mulligan; A B Abou-Samra; H Jüppner; G V Segre; H M Kronenberg
Journal:  Science       Date:  1996-08-02       Impact factor: 47.728

Review 6.  Parathyroid hormone-related protein and its receptors: nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets.

Authors:  T L Clemens; S Cormier; A Eichinger; K Endlich; N Fiaschi-Taesch; E Fischer; P A Friedman; A C Karaplis; T Massfelder; J Rossert; K D Schlüter; C Silve; A F Stewart; K Takane; J J Helwig
Journal:  Br J Pharmacol       Date:  2001-11       Impact factor: 8.739

7.  Primary hyperparathyroidism or hypercalcaemia of malignancy?

Authors:  K I Birkeland; F Gallefoss; S Olsson; E Haug
Journal:  Scand J Clin Lab Invest       Date:  1992-06       Impact factor: 1.713

8.  The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.

Authors:  H Jüppner; A B Abou-Samra; S Uneno; W X Gu; J T Potts; G V Segre
Journal:  J Biol Chem       Date:  1988-06-25       Impact factor: 5.157

9.  Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium.

Authors:  A B Abou-Samra; H Jüppner; T Force; M W Freeman; X F Kong; E Schipani; P Urena; J Richards; J V Bonventre; J T Potts
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-01       Impact factor: 11.205

10.  Presentation of a PTHrP-secreting pancreatic neuroendocrine tumour, with hypercalcaemic crisis, pre-eclampsia, and renal failure.

Authors:  P Abraham; S H Ralston; M Hewison; W D Fraser; J S Bevan
Journal:  Postgrad Med J       Date:  2002-12       Impact factor: 2.401
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