Modulation of osteoclast formation.

Osteoclasts are derived following the fusion of precursors of hematopoietic and myelomonocytic origin after appropriate stimulus, such as that afforded by RANKL and M-CSF. Thus the osteoclast can be considered as a specialized type of macrophage, and several of the factors that affect osteoclast formation also have affects upon macrophage differentiation. Inhibitors of osteoclast formation may perturb RANKL or M-CSF signalling or affect other signalling pathways. Several of these inhibitors are discussed with the view of their capacity to influence osteoclast differentiation, but not necessarily their activity.