Literature DB >> 15694301

DNA repair: the importance of phosphorylating histone H2AX.

Noel F Lowndes1, Geraldine W-L Toh.   

Abstract

How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.

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Year:  2005        PMID： 15694301     DOI： 10.1016/j.cub.2005.01.029

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


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